Watchorn D C, Sahadevan A, Egan J J, Lane S J
Department of Respiratory Medicine, AMNCH, Tallaght, Dublin 24.
Department of Respiratory Medicine, Mater Misericordiae University Hospital, Dublin 7.
Ir Med J. 2016 May 10;109(5):406.
There is an unmet need for new therapies in severe persistent asthma. Bronchial thermoplasty is a bronchoscopic procedure which employs radiofrequency energy to reduce airway smooth muscle and has been demonstrated to improve symptomatic control in severe persistent asthma in other populations. Seven patients have completed bronchial thermoplasty at a tertiary referral centre in Ireland. Asthma Control Test scores and data on hospitalisations, exacerbations, maintenance corticosteroid requirements, rescue bronchodilator use and peak expiratory flow rate (PEFR) were compared one year before and one year post treatment. Significant improvements were demonstrated in mean Asthma Control Test scores, from 8.9 to 14.7 (p = 0.036). Trends towards improvement were seen in mean hospitalisations (respective values for total in 12 month period 5.0, 0.9; p = 0.059) and PEFR (181.4 l/min, 280 l/min respectively; p = 0.059). These data support the use of bronchial thermoplasty in severe persistent asthma in the Irish population.
对于重度持续性哮喘，新疗法存在未满足的需求。支气管热成形术是一种支气管镜检查程序，它利用射频能量来减少气道平滑肌，并且已被证明在其他人群的重度持续性哮喘中可改善症状控制。七名患者在爱尔兰的一家三级转诊中心完成了支气管热成形术。比较了治疗前一年和治疗后一年的哮喘控制测试分数以及住院、病情加重、维持性皮质类固醇需求、急救支气管扩张剂使用和呼气峰值流速（PEFR）的数据。平均哮喘控制测试分数有显著改善，从8.9提高到14.7（p = 0.036）。平均住院次数（12个月期间总数分别为5.0、0.9；p = 0.059）和PEFR（分别为181.4升/分钟、280升/分钟；p = 0.059）有改善趋势。这些数据支持在爱尔兰人群的重度持续性哮喘中使用支气管热成形术。
