Rasmussen Line D, Kronborg Gitte, Larsen Carsten S, Pedersen Court, Gerstoft Jan, Obel Niels, Pottegård Anton
a Department of Infectious Diseases , Odense University Hospital , Odense , Denmark.
b Department of Infectious Diseases , Copenhagen University Hospital , Hvidovre , Denmark.
Infect Dis (Lond). 2017 Jan;49(1):42-54. doi: 10.1080/23744235.2016.1212168. Epub 2016 Aug 11.
We investigated the use of non-antiretroviral drugs in the HIV-infected compared to the general population.
From the Danish HIV Cohort Study, we identified all HIV-infected individuals older than 18 years at HIV diagnosis who received care in Denmark through 1995-2013 and reported no injection drug abuse or hepatitis C infection. Population controls were identified from The Danish Civil Registration System and matched on age and gender (5:1). We analyzed the proportion of individuals who redeemed 0-1, 2-4, 5-9, or 10 or more non-antiretroviral drugs. Data were analyzed according to calendar time, age, time from initiation of combination antiretroviral therapy (cART) and stratified by gender, geographical origin and route of HIV transmission. We further analyzed the use of the 25 most used non-antiretroviral drug classes.
We identified 4,928 HIV-infected individuals (median age: 37; 76.4% males). Overall, the HIV-infected population had a higher use of non-antiretroviral drugs compared to the background population. Whereas, the use of non-antiretroviral drugs in the HIV-infected population only changed marginally with time, the use in the background population increased considerably. Thus, use in the HIV-infected population only differed marginally from that of the background population in recent years. This difference was most pronounced in men who have sex with men (MSM).
Compared to the background population, HIV infected individuals have increased use of non-antiretroviral drugs. The excess use is mainly observed in MSM and has decreased with calendar time, why it in recent years only differs marginally from that observed in the background population.
我们调查了与普通人群相比，感染人类免疫缺陷病毒（HIV）者使用非抗逆转录病毒药物的情况。
从丹麦HIV队列研究中，我们确定了所有在1995年至2013年期间于丹麦接受治疗、诊断HIV时年龄超过18岁且报告无注射药物滥用或丙型肝炎感染的HIV感染者。通过丹麦民事登记系统确定人群对照，并按年龄和性别进行匹配（5:1）。我们分析了使用0 - 1种、2 - 4种、5 - 9种或10种及以上非抗逆转录病毒药物的个体比例。数据根据日历时间、年龄、开始联合抗逆转录病毒疗法（cART）的时间进行分析，并按性别、地理来源和HIV传播途径进行分层。我们还进一步分析了最常用的25种非抗逆转录病毒药物类别的使用情况。
我们确定了4928名HIV感染者（中位年龄：37岁；76.4%为男性）。总体而言，与背景人群相比，HIV感染人群使用非抗逆转录病毒药物的比例更高。然而，HIV感染人群中使用非抗逆转录病毒药物的情况随时间变化仅略有改变，而背景人群中的使用量则大幅增加。因此，近年来HIV感染人群中的使用情况与背景人群仅略有差异。这种差异在男男性行为者（MSM）中最为明显。
与背景人群相比，HIV感染者使用非抗逆转录病毒药物的情况有所增加。过量使用主要见于男男性行为者，且随日历时间有所减少，这就是近年来其与背景人群中观察到的情况仅略有差异的原因。
