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在感音神经性听力损失患者中,通过同时从QASSR采集ASSR和ABR来估计听力阈值。

Estimating audiometric thresholds using simultaneous acquisition of ASSR and ABR from QASSR in patients with sensorineural hearing loss.

作者信息

Lachowska Magdalena, Bohórquez Jorge, Özdamar Özcan, Niemczyk Kazimierz

机构信息

a Department of Otolaryngology , Medical University of Warsaw , Warsaw , Poland.

b Department of Biomedical Engineering, Neurosensory Laboratory , University of Miami , Coral Gables , Florida , USA , and.

出版信息

Int J Audiol. 2016 Dec;55(12):748-757. doi: 10.1080/14992027.2016.1211761. Epub 2016 Aug 9.

DOI:10.1080/14992027.2016.1211761
PMID:27686167
Abstract

OBJECTIVES

To evaluate the accuracy with which the innovative QASSR method predicts behavioral thresholds in adult patients with sensorineural hearing loss.

DESIGN

Subjects were tested at four carrier frequencies (500, 1000, 2000, and 4000 Hz).The resulting QASSR recordings were analyzed for thresholds and magnitude/phase characteristics. Tone-burst ABR was recovered from QASSR signal using CLAD method and analyzed in the time domain. The electrophysiological estimates were compared to hearing thresholds determined behaviorally.

STUDY SAMPLE

Sixteen ears of nine volunteer subjects recruited from a clinical population.

RESULTS

All mean threshold estimates differed less than 3 dB for QASSR and less than 5 dB for ABR at 1000, 2000 and 4000Hz (carrier or pure-tone test frequencies). The largest differences were observed for both at 500 Hz (5.63 and 11.56 dB respectively).The audiometric configurations of QASSR and ABR estimates followed those of the respective behaviorally determined configurations across ears tested.

CONCLUSIONS

QASSR method merges two dissimilar stimulation techniques, transient and steady-state, to create a hybrid stimulation-and-analysis paradigm that seems to improve the overall performance of the electrophysiological threshold estimation. The unique feature of the QASSR technique is the additional information afforded by the transient ABR, recovered from the same recording. The QASSR thus holds promise to be a very useful tool for practical clinical applications.

摘要

目的

评估创新的QASSR方法预测感音神经性听力损失成年患者行为阈值的准确性。

设计

对受试者在四个载波频率(500、1000、2000和4000Hz)下进行测试。对得到的QASSR记录进行阈值及幅度/相位特征分析。使用CLAD方法从QASSR信号中恢复短纯音听性脑干反应(Tone-burst ABR)并在时域中进行分析。将电生理估计值与行为测定的听力阈值进行比较。

研究样本

从临床人群中招募的9名志愿者受试者的16只耳朵。

结果

在1000、2000和4000Hz(载波或纯音测试频率)时,QASSR的所有平均阈值估计差异小于3dB,ABR的差异小于5dB。在500Hz时两者观察到的差异最大(分别为5.63和11.56dB)。在测试的各只耳朵中,QASSR和ABR估计的听力图配置均遵循各自行为测定的配置。

结论

QASSR方法融合了两种不同的刺激技术,即瞬态和稳态技术,以创建一种混合刺激与分析范式,似乎提高了电生理阈值估计的整体性能。QASSR技术的独特之处在于从同一记录中恢复的瞬态ABR提供的额外信息。因此QASSR有望成为实际临床应用中非常有用的工具。

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