Rodríguez-Leal Cristobal Manuel, López-Lunar Elena, Carrascosa-Bernáldez Jose Manuel, Provencio-Arranz Rosa Maria
a Internal Medicine Service , Instituto Psiquiátrico Servicios de Salud Mental José Germain (IPJG) , Leganés , Spain.
b Pharmacy, Instituto Psiquiátrico Servicios de Salud Mental José Germain (IPJG) , Leganés , Spain.
Int J Psychiatry Clin Pract. 2017 Mar;21(1):64-66. doi: 10.1080/13651501.2016.1234623. Epub 2016 Sep 30.
To describe a new initiative developed to optimise patient safety in a mental health setting in order to prevent serious cardiac events.
A longitudinal study of all in-patients admitted at the hospital, comprised of 197 beds distributed among three units, was conducted for 12 months. All admitted patients at the hospital underwent electrocardiogram surveillance, as it was described in our new local guideline for sudden cardiac death prevention. When electrocardiographic alterations were detected, treating physicians searched for patient's risk factors and suspicious medication and communicated the adverse event to the Pharmacy Department. These data were registered in electronic medical record system.
Over the 12-month study period, 225 patients were evaluated and 9 cases (4%) of long QT segment were detected. A multidisciplinary evaluation was done and it resulted in treatment modification and patient close monitoring. No sudden cardiac deaths occurred during the study period. Drugs more often involved in QT segment prolongation were: olanzapine, clomipramine, clozapine and risperidone.
QT segment interval enlargement is a frequent clinical problem that affects patients with mental pathology. This inexpensive initiative has allowed identifying patients at risk of sudden cardiac death and has helped to avoid mayor side effects.
描述一项为优化精神卫生机构中的患者安全以预防严重心脏事件而开展的新举措。
对该医院收治的所有住院患者进行了为期12个月的纵向研究,该医院有197张床位,分布在三个科室。所有住院患者均按照我们新的当地预防心源性猝死指南中的描述接受心电图监测。当检测到心电图改变时,主治医生查找患者的危险因素和可疑药物,并将不良事件告知药剂科。这些数据记录在电子病历系统中。
在为期12个月的研究期间,共评估了225例患者,检测到9例(4%)长QT段病例。进行了多学科评估,结果是调整治疗方案并对患者进行密切监测。研究期间未发生心源性猝死。更常导致QT段延长的药物有:奥氮平、氯米帕明、氯氮平和利培酮。
QT段间期延长是一个影响精神疾病患者的常见临床问题。这项低成本举措能够识别有心源性猝死风险的患者,并有助于避免主要的副作用。