Jia Chong-Fu, Jiang Yi-Nong, Yang Zhi-Qiang, Sun Xi-Xia, Yu Yang, Wang Hao, Lu Yan, Chen Ai-Jun, Wang Zhao-Qian
Department of Cardiovascular Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
Am J Hypertens. 2017 Jan;30(1):61-66. doi: 10.1093/ajh/hpw126. Epub 2016 Sep 29.
A new feature of coronary computed tomography angiography (CTA) is to estimate ascending aortic elasticity without additional cost, but its applicable benefit for prehypertension patients is still unclear. The aim of this study is to discuss the characteristic of ascending aortic elasticity for specific prehypertension patients and its risk factors.
Coronary CTA examinations of 398 participants were performed using a 128 slicer CT scanner. The differences of 3 ascending aortic elasticity related indices, including aortic distensibility (AD), aortic compliance (AC), and aortic stiffness (ASI), and anatomical measurements were analyzed among the normal, prehypertension, and primary hypertension groups.
No difference was found for normalized minimum cross-sectional diameter and area for the ascending aorta between prehypertension and normal groups. AD, AC, and ASI were significantly different in 3 groups. Between prehypertension and normal groups, AD and AC were found much smaller but no difference were found for ASI; while between prehypertension and hypertension groups, significant differences were found in AD and ASI, and AC was found to a lesser extent. Risk factor study for prehypertension patients indicated that age and systolic pressure were the independent risk factors for AD decline.
As a byproduct, coronary CTA can provide multiple aortic elasticity related indices for the prehypertension patients, without additional contrast media consumption and radiation dose. It is proofed that the early detection of ascending aortic elasticity index changes, especially for AD are essential for identifying the high-risk individuals in the prehypertension populations.
Our public trials registry number ChiCTR-RIC-15007482.
冠状动脉计算机断层扫描血管造影（CTA）的一项新特性是无需额外费用即可评估升主动脉弹性，但其对高血压前期患者的适用益处仍不明确。本研究的目的是探讨特定高血压前期患者升主动脉弹性的特征及其危险因素。
使用128层CT扫描仪对398名参与者进行冠状动脉CTA检查。分析了正常组、高血压前期组和原发性高血压组之间3个与升主动脉弹性相关的指标，包括主动脉扩张性（AD）、主动脉顺应性（AC）和主动脉僵硬度（ASI）以及解剖学测量值的差异。
高血压前期组与正常组之间升主动脉的标准化最小横截面直径和面积无差异。3组之间的AD、AC和ASI有显著差异。在高血压前期组和正常组之间，发现AD和AC小得多，但ASI无差异；而在高血压前期组和高血压组之间，AD和ASI有显著差异，AC差异较小。对高血压前期患者的危险因素研究表明，年龄和收缩压是AD下降的独立危险因素。
作为一种副产品，冠状动脉CTA可为高血压前期患者提供多个与主动脉弹性相关的指标，而无需额外使用造影剂和增加辐射剂量。事实证明，早期发现升主动脉弹性指数变化，尤其是AD变化，对于识别高血压前期人群中的高危个体至关重要。
我们的公共试验注册号为ChiCTR-RIC-15007482。
