突触更新：一种获得突触特异性的机制。
Synapse turnover: a mechanism for acquiring synaptic specificity.
作者信息
Ruffolo R R, Eisenbarth G S, Thompson J M, Nirenberg M
出版信息
Proc Natl Acad Sci U S A. 1978 May;75(5):2281-5. doi: 10.1073/pnas.75.5.2281.
Neurons are generated in chick retina that are able to form synapses with striated muscle cells for only a brief period during embryonic development. The ability to form synapses is lost with a half-life of 21 hr. Retina neuron-myotube synapses form rapidly but soon are terminated. Chick embryo spinal cord neurons also form synapses with muscle cells for only a limited time during development, but these synapses are long lived. These results show that different classes of synapses turn over at different rates and suggest that part of the specificity of synaptic circuits may be acquired during development by a process of selection based on synapse termination rates.
在鸡胚视网膜中生成的神经元，在胚胎发育期间仅在一段短暂的时期内能够与横纹肌细胞形成突触。形成突触的能力以21小时的半衰期丧失。视网膜神经元-肌管突触迅速形成，但很快就会终止。鸡胚脊髓神经元在发育过程中也仅在有限的时间内与肌肉细胞形成突触，但这些突触寿命很长。这些结果表明，不同类型的突触更新速率不同，并表明突触回路特异性的一部分可能是在发育过程中通过基于突触终止速率的选择过程获得的。
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