• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

从视网膜分离出的神经元的突触和乙酰胆碱受体合成。

Synapse and acetylcholine receptor synthesis by neurons dissociated from retina.

作者信息

Vogel Z, Daniels M P, Nirenberg M

出版信息

Proc Natl Acad Sci U S A. 1976 Jul;73(7):2370-4. doi: 10.1073/pnas.73.7.2370.

DOI:10.1073/pnas.73.7.2370
PMID:1065888
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC430571/
Abstract

Neurons dissociated from chick embryo retina and cultured from more than 1 x 10(8) synapses per mg of protein. At least three types of synapses are synthesized which resemble those of the intact retina. In addition, two populations of neurons were found, those with nicotinic acetylcholine receptors and those without the receptors.

摘要

从鸡胚视网膜解离的神经元，每毫克蛋白质培养出超过1×10⁸个突触。至少合成了三种类型的突触，它们类似于完整视网膜中的突触。此外，还发现了两类神经元，一类有烟碱型乙酰胆碱受体，另一类没有该受体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b999/430571/1a04f647d59c/pnas00037-0212-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b999/430571/4a0d77d68aa3/pnas00037-0210-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b999/430571/2b4d30a5feda/pnas00037-0211-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b999/430571/f74dd05cc630/pnas00037-0211-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b999/430571/dff81633b2e7/pnas00037-0212-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b999/430571/1a04f647d59c/pnas00037-0212-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b999/430571/4a0d77d68aa3/pnas00037-0210-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b999/430571/2b4d30a5feda/pnas00037-0211-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b999/430571/f74dd05cc630/pnas00037-0211-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b999/430571/dff81633b2e7/pnas00037-0212-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b999/430571/1a04f647d59c/pnas00037-0212-b.jpg

相似文献

1
Synapse and acetylcholine receptor synthesis by neurons dissociated from retina.从视网膜分离出的神经元的突触和乙酰胆碱受体合成。
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2370-4. doi: 10.1073/pnas.73.7.2370.
2
Localization of acetylcholine receptors during synaptogenesis in retina.视网膜突触发生过程中乙酰胆碱受体的定位
Proc Natl Acad Sci U S A. 1976 Jun;73(6):1806-10. doi: 10.1073/pnas.73.6.1806.
3
Extra-synaptic localization of alpha-bungarotoxin receptors in cultured chick ciliary ganglion neurons.α-银环蛇毒素受体在培养的鸡睫状神经节神经元中的突触外定位
Brain Res. 1983 Jun 13;269(1):172-6. doi: 10.1016/0006-8993(83)90977-0.
4
Identification of synaptic acetylcholine receptor sites in retina with peroxidase-labeled alpha-bungarotoxin.用辣根过氧化物酶标记的α-银环蛇毒素鉴定视网膜中的突触乙酰胆碱受体位点。
Proc Natl Acad Sci U S A. 1977 Aug;74(8):3268-72. doi: 10.1073/pnas.74.8.3268.
5
Localization of alpha-bungarotoxin binding sites in synapses of the developing chick retina.α-银环蛇毒素结合位点在发育中的雏鸡视网膜突触中的定位。
Brain Res. 1980 Nov 10;201(1):45-56. doi: 10.1016/0006-8993(80)90774-x.
6
Localization of cholinergic synapses in mammalian retina with peroxidase-conjugated alpha-bungarotoxin.
Vision Res. 1979;19(3):287-92. doi: 10.1016/0042-6989(79)90174-3.
7
Synaptic localization of alpha-bungarotoxin binding which blocks nicotinic transmission at frog sympathetic neurons.α-银环蛇毒素结合的突触定位，其阻断青蛙交感神经元的烟碱传递。
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1948-52. doi: 10.1073/pnas.78.3.1948.
8
Synapse formation and induction of acetylcholine receptors by spinal neurones in cocultures with sympathetic ganglion and muscle cells.在与交感神经节和肌肉细胞共培养时，脊髓神经元的突触形成及乙酰胆碱受体的诱导。
Dev Neurosci. 1986;8(2):76-88. doi: 10.1159/000112243.
9
Nonequivalence of alpha-bungarotoxin receptors and acetylcholine receptors in chick sympathetic neurons.鸡交感神经元中α-银环蛇毒素受体与乙酰胆碱受体的不等效性
Proc Natl Acad Sci U S A. 1978 Feb;75(2):1016-20. doi: 10.1073/pnas.75.2.1016.
10
[Scanning electron microscopy and light microscopy studies on the retina of chick embryos in cell culture].[细胞培养中鸡胚视网膜的扫描电子显微镜和光学显微镜研究]
J Hirnforsch. 1986;27(6):587-96.

引用本文的文献

1
Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils.涉及乙酰胆碱酯酶和β-淀粉样肽的稳定复合物会改变该酶的生化特性，并增加阿尔茨海默病原纤维的神经毒性。
J Neurosci. 1998 May 1;18(9):3213-23. doi: 10.1523/JNEUROSCI.18-09-03213.1998.
2
Dynorphins modulate DNA synthesis in fetal brain cell aggregates.强啡肽调节胎儿脑细胞聚集体中的DNA合成。
J Neurochem. 1995 Oct;65(4):1481-6. doi: 10.1046/j.1471-4159.1995.65041481.x.
3
Regulation of dopamine- and adenosine-dependent adenylate cyclase systems of chicken embryo retina cells in culture.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Plaque formation and isolation of pure lines with poliomyelitis viruses.脊髓灰质炎病毒的噬斑形成及纯系分离
J Exp Med. 1954 Feb;99(2):167-82. doi: 10.1084/jem.99.2.167.
3
New-forming retinal synapses in vitro.体外新形成的视网膜突触。
培养的鸡胚视网膜细胞中多巴胺和腺苷依赖性腺苷酸环化酶系统的调节
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5708-12. doi: 10.1073/pnas.79.18.5708.
4
Differentiation of neuronal growth cones: specialization of filopodial tips for adhesive interactions.神经元生长锥的分化：丝状伪足尖端在黏附相互作用中的特化。
Proc Natl Acad Sci U S A. 1985 Dec;82(23):8256-60. doi: 10.1073/pnas.82.23.8256.
5
Monoclonal antibody 18B8 detects gangliosides associated with neuronal differentiation and synapse formation.单克隆抗体18B8可检测与神经元分化和突触形成相关的神经节苷脂。
Proc Natl Acad Sci U S A. 1985 Jun;82(12):4008-12. doi: 10.1073/pnas.82.12.4008.
6
Molecular basis of growth cone adhesion: anchoring of adheron-containing filaments at adhesive loci.生长锥黏附的分子基础：含黏附子细丝在黏附位点的锚定。
J Cell Biol. 1988 Jun;106(6):2095-108. doi: 10.1083/jcb.106.6.2095.
7
Glutamic acid decarboxylase of embryonic avian retina cells in culture: regulation by gamma-aminobutyric acid (GABA).培养的胚胎鸡视网膜细胞中的谷氨酸脱羧酶：γ-氨基丁酸（GABA）的调节作用
Cell Mol Neurobiol. 1991 Oct;11(5):485-96. doi: 10.1007/BF00734811.
8
Adhesion among neural cells of the chick embryo. III. Relationship of the surface molecule CAM to cell adhesion and the development of histotypic patterns.鸡胚神经细胞间的黏附。III. 表面分子细胞黏附分子（CAM）与细胞黏附及组织型模式发育的关系。
J Cell Biol. 1978 Nov;79(2 Pt 1):371-81. doi: 10.1083/jcb.79.2.371.
9
Differentiation of chick embryo neuroretina cells in monolayer cultures. An ultrastructural study. I. Seven-day retina.鸡胚神经视网膜细胞在单层培养中的分化。超微结构研究。I. 七日龄视网膜。
Cell Tissue Res. 1977 Dec 13;185(2):159-73. doi: 10.1007/BF00220661.
10
Monoclonal antibody to a plasma membrane antigen of neurons.针对神经元质膜抗原的单克隆抗体。
Proc Natl Acad Sci U S A. 1979 Oct;76(10):4913-7. doi: 10.1073/pnas.76.10.4913.
Experientia. 1967 Mar 15;23(3):199-200. doi: 10.1007/BF02136284.
4
Electron microscopic analysis of aggregation of embryonic cells: the structure and differentiation of aggregates of neural retina cells.胚胎细胞聚集的电子显微镜分析：神经视网膜细胞聚集体的结构与分化
Dev Biol. 1970 Sep;23(1):36-61. doi: 10.1016/s0012-1606(70)80006-9.
5
Organization of vertebrate retinas.脊椎动物视网膜的组织结构。
Invest Ophthalmol. 1970 Sep;9(9):655-80.
6
Intercellular junctions in the developing neural retina of the chick embryo.鸡胚发育中的神经视网膜中的细胞间连接。
Z Zellforsch Mikrosk Anat. 1970;104(3):405-18. doi: 10.1007/BF00335691.
7
On the synaptogenic sequence in the chick retina.
Anat Rec. 1974 Jul;179(3):297-301. doi: 10.1002/ar.1091790302.
8
Nerve-muscle interaction in vitro. Role of acetylcholine.体外神经-肌肉相互作用。乙酰胆碱的作用。
J Gen Physiol. 1973 Sep;62(3):255-70. doi: 10.1085/jgp.62.3.255.
9
Acetycholine receptor production and incorporation into membranes of developing muscle fibers.乙酰胆碱受体的产生及整合到发育中肌纤维的膜中。
Dev Biol. 1973 Jan;30(1):153-65. doi: 10.1016/0012-1606(73)90054-7.
10
Effects of a snake alpha-neurotoxin on the development of innervated skeletal muscles in chick embryo.一种蛇α-神经毒素对鸡胚中受神经支配的骨骼肌发育的影响。
Proc Natl Acad Sci U S A. 1973 Jun;70(6):1708-12. doi: 10.1073/pnas.70.6.1708.