使用神经黑色素敏感磁共振成像对蓝斑和黑质成像的可重复性。
Reproducibility of locus coeruleus and substantia nigra imaging with neuromelanin sensitive MRI.
作者信息
Langley Jason, Huddleston Daniel E, Liu Christine J, Hu Xiaoping
机构信息
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Center for Advanced Neuroimaging, University of California, Riverside, Riverside, CA, USA.
出版信息
MAGMA. 2017 Apr;30(2):121-125. doi: 10.1007/s10334-016-0590-z. Epub 2016 Sep 29.
OBJECTIVES
The purpose of this study was to assess the reproducibility of substantia nigra pars compacta (SNpc) and locus coeruleus (LC) delineation and measurement with neuromelanin-sensitive MRI.
MATERIALS AND METHODS
Eleven subjects underwent two neuromelanin-sensitive MRI scans. SNpc and LC volumes were extracted for each scan. Reproducibility of volume and magnetization transfer contrast measurements in SNpc and LC was assessed using intraclass correlation coefficients (ICC) and dice similarity coefficients (DSC).
RESULTS
SNpc and LC volume measurements showed excellent reproducibility (SNpc-ICC: 0.94, p < 0.001; LC-ICC: 0.96, p < 0.001). SNpc and LC were accurately delineated between scans (SNpc-DSC: 0.80 ± 0.03; LC-DSC: 0.63 ± 0.07).
CONCLUSION
Neuromelanin-sensitive MRI can consistently delineate SNpc and LC.
目的
本研究旨在评估使用对神经黑色素敏感的磁共振成像（MRI）对黑质致密部（SNpc）和蓝斑（LC）进行描绘和测量的可重复性。
材料与方法
11名受试者接受了两次对神经黑色素敏感的MRI扫描。每次扫描均提取SNpc和LC的体积。使用组内相关系数（ICC）和骰子相似系数（DSC）评估SNpc和LC体积及磁化传递对比测量的可重复性。
结果
SNpc和LC体积测量显示出极佳的可重复性（SNpc-ICC：0.94，p < 0.001；LC-ICC：0.96，p < 0.001）。SNpc和LC在各次扫描之间被准确描绘（SNpc-DSC：0.80 ± 0.03；LC-DSC：0.63 ± 0.07）。
结论
对神经黑色素敏感的MRI能够持续清晰地描绘SNpc和LC。
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