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西奈半岛东部维和部队中的皮肤利什曼病

Cutaneous leishmaniasis in the peace keeping force in East Sinai.

作者信息

Mansour N S, Youssef F G, Mohareb E W, Dees W H, Karuru E R

出版信息

J Egypt Soc Parasitol. 1989 Dec;19(2):725-32.

PMID:2768872
Abstract

During the period from October 1982 to July 1985 cutaneous leishmaniasis was diagnosed in 113 Multinational Force and Observers (MFO) soldiers from various nations, East Sinai. Leishmania was isolated from twelve of these patients and maintained in vitro using Tanabe's medium. Intrasplenic inoculation of promastigotes from isolate cultures into hamsters resulted in dissemination patterns typical of cutaneous leishmaniasis. The excreted factor in culture when serotyped against known marker strains indicated subserotype A1B2. They also exhibited similar banding patterns to L. major L-137 for GPI, G 6-PD, MDH, NH, MPI, PGM and variant B for 6-PGDH. This leishmaniasis focus appears epidemiologically similar to that of nearby Mid Western Negev where transmission involves Phlebotomus papatasi, Psammomys, and Meriones.

摘要

在1982年10月至1985年7月期间,东奈盖夫的多国部队和观察员(MFO)中来自不同国家的113名士兵被诊断出患有皮肤利什曼病。从其中12名患者身上分离出利什曼原虫,并使用田边培养基在体外进行培养。将分离培养物中的前鞭毛体接种到仓鼠脾脏内,导致出现典型的皮肤利什曼病传播模式。培养物中的分泌因子与已知标记菌株进行血清分型时,显示为A1B2亚型。它们在糖基磷脂酰肌醇(GPI)、葡萄糖-6-磷酸脱氢酶(G 6-PD)、苹果酸脱氢酶(MDH)、谷氨酰胺酶(NH)、磷酸甘露糖异构酶(MPI)、磷酸葡萄糖变位酶(PGM)方面也表现出与硕大利什曼原虫L-137相似的条带模式,在6-磷酸葡萄糖酸脱氢酶(6-PGDH)方面表现出与变种B相似的条带模式。这个利什曼病疫源地在流行病学上似乎与附近的中西部内盖夫相似,那里的传播涉及巴氏白蛉、肥尾沙鼠和子午沙鼠。

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