Sawatari K, Imai Y, Kurosawa H, Fukuchi S, Kawada M, Matsuo K, Aoki M, Yamagishi M, Ohta J, Nakazawa M
Nihon Kyobu Geka Gakkai Zasshi. 1989 Feb;37(2):208-17.
A new selection criterion for Fontan procedure, pulmonary artery clamping test (PACT) was developed and employed in 13 candidates for Fontan procedure. PACT was aimed to evaluate the response of pulmonary vascular bed to increased pulmonary blood flow and calculate the pulmonary vascular resistance in the increased pulmonary blood flow as a selection criterion for Fontan procedure, preoperatively. After a median sternotomy incision, an electromagnetic flow meter was employed for measuring the pulmonary blood flow (Qp) on the pulmonary trunk. By clamping the left pulmonary artery and the right pulmonary artery, right pulmonary vascular resistance and the left pulmonary resistance in the pulmonary blood flow of Qp were calculated respectively. By means of electrical analogue, right and left lungs were simulated as resistors in parallel. And the equivalent pulmonary vascular resistance Rpc was calculated as the predicted pulmonary vascular resistance in the increased pulmonary blood flow of two times Qp. Fontan procedure was performed in 9 cases with a Rpc of less than 3 unit.m2 with a successful result and no death. Postoperative cardiac index ranged from 2.6 to 3.7 L/min.m2 with a mean of 2.8 L/min.m2. Postoperative pulmonary vascular resistance ranged from 1.6 to 3.2 unit.m2. Postoperative cardiac index was correlated with postoperative pulmonary vascular resistance. And postoperative pulmonary vascular resistance was well correlated with equivalent pulmonary vascular resistance but was not correlated with preoperative pulmonary vascular resistance measured by Fick's method at the preoperative catheterization. In Fontan procedure, the pulmonary blood flow frequently increases to a certain degree postoperatively. And pulmonary vascular resistance is not a static resistance, but a dynamic resistance. Hence, in discussing a pulmonary vascular resistance as a selection criterion for Fontan procedure, the pulmonary blood flow in which the pulmonary vascular resistance stand should be taken into account. Equivalent pulmonary vascular resistance Qpc is a theoretical selection criterion for Fontan procedure and well reflects the postoperative pulmonary vascular resistance. Fontan procedure can be successfully performed with a Rpc of less than 3 unit.m2.
一种用于Fontan手术的新选择标准——肺动脉钳夹试验(PACT)被研发出来,并应用于13例Fontan手术候选患者。PACT旨在评估肺血管床对肺血流量增加的反应,并计算增加肺血流量时的肺血管阻力,作为Fontan手术术前的选择标准。经正中胸骨切开术后,使用电磁流量计测量肺动脉主干的肺血流量(Qp)。通过钳夹左肺动脉和右肺动脉,分别计算Qp肺血流量时的右肺血管阻力和左肺血管阻力。借助电模拟,将右肺和左肺模拟为并联的电阻器。并计算等效肺血管阻力Rpc,作为两倍Qp增加肺血流量时的预测肺血管阻力。9例Rpc小于3单位·m²的患者成功进行了Fontan手术,无死亡病例。术后心脏指数为2.6至3.7L/min·m²,平均为2.8L/min·m²。术后肺血管阻力为1.6至3.2单位·m²。术后心脏指数与术后肺血管阻力相关。术后肺血管阻力与等效肺血管阻力相关性良好,但与术前心导管检查时用Fick法测得的术前肺血管阻力无关。在Fontan手术中,术后肺血流量经常会增加到一定程度。而且肺血管阻力不是一个静态阻力,而是一个动态阻力。因此,在讨论将肺血管阻力作为Fontan手术的选择标准时,应考虑肺血管阻力所对应的肺血流量。等效肺血管阻力Qpc是Fontan手术的一个理论选择标准,能很好地反映术后肺血管阻力。Rpc小于3单位·m²时可成功进行Fontan手术。