Zheng Zhuojun, Li Xiaodong, Zhu Yuandong, Gu Weiying, Xie Xiaobao, Jiang Jingting
Department of Hematology, The Third Affiliated Hospital of Soochow University, China.
Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, China.
Oncotarget. 2016 Nov 1;7(44):71526-71535. doi: 10.18632/oncotarget.12245.
This study was designed to perform an acceptable prognostic nomogram for acute myeloid leukemia. The clinical data from 311 patients from our institution and 165 patients generated with Cancer Genome Atlas Research Network were reviewed. A prognostic nomogram was designed according to the Cox's proportional hazard model to predict overall survival (OS). To compare the capacity of the nomogram with that of the current prognostic system, the concordance index (C-index) was used to validate the accuracy as well as the calibration curve. The nomogram included 6 valuable variables: age, risk stratifications based on cytogenetic abnormalities, status of FLT3-ITD mutation, status of NPM1 mutation, expression of CD34, and expression of HLA-DR. The C-indexes were 0.71 and 0.68 in the primary and validation cohort respectively, which were superior to the predictive capacity of the current prognostic systems in both cohorts. The nomogram allowed both patients with acute myeloid leukemia and physicians to make prediction of OS individually prior to treatment.
本研究旨在构建一个可接受的急性髓系白血病预后列线图。回顾了来自本机构的311例患者以及由癌症基因组图谱研究网络生成的165例患者的临床数据。根据Cox比例风险模型设计了一个预后列线图，以预测总生存期（OS）。为了将列线图的预测能力与当前预后系统进行比较，使用一致性指数（C指数）来验证准确性以及校准曲线。该列线图包含6个有价值的变量：年龄、基于细胞遗传学异常的风险分层、FLT3-ITD突变状态、NPM1突变状态、CD34表达以及HLA-DR表达。在初级队列和验证队列中，C指数分别为0.71和0.68，均优于两个队列中当前预后系统的预测能力。该列线图使急性髓系白血病患者和医生在治疗前均可单独对总生存期进行预测。
