Kini R Manjunatha, Koh Cho Yeow
Protein Science Laboratory, Department of Biological Sciences, Faculty of Science, 14 Science Drive 4, National University of Singapore, Singapore 117543, Singapore.
Toxins (Basel). 2016 Sep 29;8(10):284. doi: 10.3390/toxins8100284.
Snake venom metalloproteases, in addition to their contribution to the digestion of the prey, affect various physiological functions by cleaving specific proteins. They exhibit their activities through activation of zymogens of coagulation factors, and precursors of integrins or receptors. Based on their structure-function relationships and mechanism of action, we have defined classification and nomenclature of functional sites of proteases. These metalloproteases are useful as research tools and in diagnosis and treatment of various thrombotic and hemostatic conditions. They also contribute to our understanding of molecular details in the activation of specific factors involved in coagulation, platelet aggregation and matrix biology. This review provides a ready reference for metalloproteases that interfere in blood coagulation, fibrinolysis and platelet aggregation.
蛇毒金属蛋白酶除了有助于猎物的消化外，还通过切割特定蛋白质影响各种生理功能。它们通过激活凝血因子的酶原、整合素或受体的前体来发挥其活性。基于它们的结构-功能关系和作用机制，我们已经定义了蛋白酶功能位点的分类和命名。这些金属蛋白酶可用作研究工具，以及用于各种血栓形成和止血病症的诊断和治疗。它们还有助于我们理解凝血、血小板聚集和基质生物学中涉及的特定因子激活的分子细节。本综述为干扰血液凝固、纤维蛋白溶解和血小板聚集的金属蛋白酶提供了一份现成的参考资料。
