Deltour I, Tsareva Y, Schonfeld S J, Vostrotin V V, Okatenko P, Sokolnikov M, Schüz J
a Section of Environment and Radiation, International Agency for Research on Cancer (IARC), Lyon, France; and.
b Epidemiology Laboratory and Laboratory of Radiation Safety, Southern Urals Biophysics Institute (SUBI), Ozyorsk, Russia.
Radiat Res. 2016 Oct;186(4):415-421. doi: 10.1667/RR14399.1. Epub 2016 Sep 30.
Long-term effects of in utero exposure to ionizing radiation remain poorly quantified in humans. In this study, the risk of hematologic malignancies was investigated in offspring of female workers of the Mayak Production Association, a large Russian nuclear facility. Excess relative risks (ERR) for exposure to gamma radiation and plutonium were estimated in a cohort of 8,466 offspring who were born between January 1, 1948 and December 31, 1988 and followed until 2009. An unstable linear ERR of 1.12 (95% CI 0.11-3.44) per 100 mGy gamma exposure in utero was estimated based on 32 incident hematologic malignancies in 277,002 person-years under risk. The ERR was increased in the dose category 20-79 mGy gamma exposure in utero (1.75, 95% CI 0.04; 5.63), while the other dose categories showed decreased or unstable estimates. Leukemia showed an ERR of 1.76 (95% CI 0.01-8.33) per 100 mGy based on 13 cases. There was no consistent association with plutonium exposure. While an increased risk of hematologic malignancies after gamma exposure in utero was suggested, the small numbers prevented more definitive conclusions.
子宫内暴露于电离辐射对人类的长期影响仍未得到充分量化。在本研究中，对俄罗斯大型核设施玛雅克生产协会女性工人的后代患血液系统恶性肿瘤的风险进行了调查。在一组8466名后代中估计了暴露于伽马辐射和钚的超额相对风险（ERR），这些后代出生于1948年1月1日至1988年12月31日之间，并随访至2009年。根据277,002人年风险期内发生的32例血液系统恶性肿瘤，估计子宫内每100 mGy伽马暴露的不稳定线性ERR为1.12（95%CI 0.11 - 3.44）。子宫内伽马暴露剂量在20 - 79 mGy类别中ERR增加（1.75，95%CI 0.04；5.63），而其他剂量类别显示ERR估计值降低或不稳定。基于13例病例，白血病每100 mGy的ERR为1.76（95%CI 0.01 - 8.33）。与钚暴露没有一致的关联。虽然提示子宫内伽马暴露后血液系统恶性肿瘤风险增加，但由于病例数少，无法得出更明确的结论。
