Centre for Nanoscience and Technology, Pondicherry University, Puducherry, 605 014, India.
Medical Imaging Research Centre, Dayananda Sagar Institutions, Bangalore, India.
J Biomed Mater Res B Appl Biomater. 2017 Nov;105(8):2545-2552. doi: 10.1002/jbm.b.33775. Epub 2016 Sep 30.
To compensate the limitations of bone tissue magnetic resonance imaging (MRI), a series of gadolinium (Gd ) substituted β-Tricalcium phosphate [β-TCP, β-Ca (PO ) ] were developed. All the powders were characterized using XRD, Raman spectroscopy, Rietveld refinement of the XRD data and the studies confirmed the Gd occupancy at Ca (1), Ca (2) and Ca (3) lattice sites of β-Ca (PO ) HR-TEM analysis revealed the spherical nature of particles with diameter about 100 nm. The Gd doped β-Ca (PO ) exhibited non-toxic behaviour to MG-63 cells in vitro and the room temperature magnetic field versus magnetization measurements confirmed its paramagnetic behaviour. MRI analysis revelas that it shorten both T and T proton relaxation times, thus influencing both r and r relaxivity values that reach 61.97 mM s and 73.35 mM s . © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2545-2552, 2017.
为了弥补骨组织磁共振成像（MRI）的局限性，开发了一系列钆（Gd）取代的β-磷酸三钙[β-TCP，β-Ca（PO）]。所有粉末均采用 XRD、拉曼光谱、XRD 数据的 Rietveld 精修和研究进行了表征，并证实了 Gd 占据β-Ca（PO）的 Ca（1）、Ca（2）和 Ca（3）晶格位。高分辨率透射电子显微镜（HR-TEM）分析表明，颗粒具有约 100nm 的球形性质。Gd 掺杂的β-Ca（PO）在体外对 MG-63 细胞表现出非毒性行为，室温磁场与磁化率测量证实了其顺磁性行为。MRI 分析表明，它缩短了质子 T 和 T 的弛豫时间，从而影响了 r 和 r 弛豫率值，分别达到 61.97mM s 和 73.35mM s。©2016 年 Wiley 期刊，生物医学材料研究杂志 B：应用生物材料，105B：2545-2552，2017 年。
