[Cleido-cranial dysplasia. Contribution to study of this disease on the basis of four cases (author's transl)].

First described in 1898 under the name of cleido-cranial dysostosis by Pierre Marie and Sainton, this hereditary disease is highly polymorphous and progressive, hence the multiplicity of its manifestations. These involve not only the skull and clavicle, but also the hands, the spine and the teeth. In fact, it is disturbance of growth rather than a dysostosis in the strict sense of the term. Its mode of transmission is dominant. Its pathogenesis is totally unknown.