Taylor Catherine E
Colorado Springs, Colorado, USA.
Med Hypotheses. 2016 Oct;95:31-33. doi: 10.1016/j.mehy.2016.08.007. Epub 2016 Aug 16.
Nausea and vomiting of pregnancy (NVP) remains difficult to treat. Last century, thalidomide was used to alleviate NVP, but it caused teratogenesis by interfering with angiogenesis. The gasotransmitters hydrogen sulfide (H2S) and nitric oxide are mutually dependent on each other for their angiogenesis-related functions. Pregnancy-related requirements for increased endogenous H2S could create a temporary excess of sulfite, an H2S catabolite, which is toxic and can induce nausea. Sulfite oxidase, a molybdenum-containing enzyme, catalyzes oxidation of sulfite to sulfate, which can then be excreted or reused by the body. Supplementation with molybdenum should facilitate enhanced sulfite oxidase activity, thus lowering gestationally-elevated sulfite levels in the gastrointestinal tract and easing NVP.
妊娠恶心呕吐（NVP）仍然难以治疗。上世纪，沙利度胺被用于缓解妊娠恶心呕吐，但它通过干扰血管生成导致了致畸作用。气体信号分子硫化氢（H2S）和一氧化氮在其与血管生成相关的功能上相互依赖。妊娠相关的内源性H2S增加需求可能会导致亚硫酸盐（一种H2S分解代谢产物）暂时过量，亚硫酸盐有毒且可诱发恶心。亚硫酸盐氧化酶是一种含钼酶，催化亚硫酸盐氧化为硫酸盐，然后硫酸盐可被身体排泄或再利用。补充钼应有助于增强亚硫酸盐氧化酶的活性，从而降低胃肠道中妊娠期间升高的亚硫酸盐水平并缓解妊娠恶心呕吐。
