Department of Surgical Oncology, University of Tokyo, Tokyo, Japan.
Department of Surgical Oncology, University of Tokyo, Tokyo, Japan.
Asian J Surg. 2018 May;41(3):197-202. doi: 10.1016/j.asjsur.2016.07.013. Epub 2016 Sep 29.
Colorectal cancer is seldom accompanied by venous tumor thrombosis, and little is known about the features of venous tumor thrombosis in colorectal cancer. However, some reports show that colorectal cancer patients can develop venous tumor thrombosis and warn clinicians not to overlook this complication. In this report, we perform a review of 43 previously reported cases and investigate the characteristics of colorectal cancer accompanied by venous tumor thrombosis. The histological type of more than half of the cases was moderately differentiated adenocarcinoma, which is known to be aggressive. Among 41 cases with available data on liver metastasis, eight patients had synchronous liver metastasis, and liver metastatic recurrence after surgical resection was indicated in 10 patients. This liver metastatic rate was high compared to general colorectal cancer. However, 11 of 43 patients with venous tumor thrombosis could survive for more than 2 years after the diagnosis, although five of the 11 patients had liver metastasis. A long survival can be anticipated for patients following complete tumor resection and adjuvant chemotherapy. A greater accumulation of cases will help elucidate the characteristics of colorectal cancer with venous tumor thrombosis and improve the treatment strategy.
结直肠癌很少伴有静脉肿瘤血栓，关于结直肠癌静脉肿瘤血栓的特征知之甚少。然而，一些报告表明，结直肠癌患者可能会发生静脉肿瘤血栓，并提醒临床医生不要忽视这种并发症。在本报告中，我们对之前报道的 43 例病例进行了回顾性研究，并探讨了伴有静脉肿瘤血栓的结直肠癌的特征。超过一半病例的组织学类型为中分化腺癌，这是一种侵袭性肿瘤。在 41 例有肝转移数据的病例中，8 例为同步肝转移，10 例患者术后出现肝转移复发。与一般结直肠癌相比，肝转移率较高。然而，43 例静脉肿瘤血栓患者中有 11 例在诊断后存活超过 2 年，尽管其中 5 例有肝转移。对于完全肿瘤切除和辅助化疗的患者，可以预期长期生存。更多病例的积累将有助于阐明伴有静脉肿瘤血栓的结直肠癌的特征，并改善治疗策略。
