Ivković Maja, Pantović-Stefanović Maja, Petronijević Nataša, Dunjić-Kostić Bojana, Velimirović Milica, Nikolić Tatjana, Jurišić Vladimir, Lačković Maja, Totić-Poznanović Sanja, Jovanović Aleksandar A, Damjanović Aleksandar
Clinic of Psychiatry, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia; School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
Clinic of Psychiatry, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia.
J Affect Disord. 2017 Jan 1;207:47-52. doi: 10.1016/j.jad.2016.09.017. Epub 2016 Sep 22.
Affective temperaments are intermediate phenotypes for major affective disorders and are reported to have a neuroimmune etiopathogenesis. Here we investigated the role of soluble intercellular cell adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in affective temperaments and mood symptoms in healthy adults.
Healthy adults (n=94) were screened for psychiatric disorders using the nonpatient version of the Structured Clinical Interview for DSM-IV-I and II. Subjects with medical conditions associated with changes in inflammatory response were excluded, deriving the final sample (n=68). Affective temperaments were evaluated with Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Autoquestionnaire (TEMPS-A). State mood symptoms were assessed using the Young Mania Rating Scale and Montgomery-Åsberg Depression Rating Scale. Serum sICAM-1 and sVCAM-1 levels were measured using enzyme-linked immunosorbent assay.
After adjusting for confounders (age, gender, BMI, and smoking habits), a high negative correlation between depressive and irritable temperament TEMPS-A scores and sVCAM-1 levels was detected. Although we identified no association between sICAM-1 levels and affective temperament scores, sICAM-1 was related to the state severity of manic symptoms. In a multiple linear regression model, sVCAM-1 remained a significant predictor of depressive but not irritable temperament scores.
The temperaments were estimated on the basis of self-report questionnaire.
Our findings suggest that sVCAM-1 is related to affective temperaments, and it is a trait marker for liability to mood disorders. This relationship between alterations in cellular adhesion and affective temperament may be important for vulnerability to affective disorders.
情感气质是主要情感障碍的中间表型，据报道具有神经免疫病因。在此，我们研究了可溶性细胞间黏附分子-1（sICAM-1）和可溶性血管细胞黏附分子-1（sVCAM-1）在健康成年人情感气质和情绪症状中的作用。
使用《精神疾病诊断与统计手册》第四版修订版和第二版的非患者版结构化临床访谈对94名健康成年人进行精神疾病筛查。排除患有与炎症反应变化相关疾病的受试者，最终样本为68人。使用孟菲斯、比萨、巴黎和圣地亚哥气质评估-自填问卷（TEMPS-A）评估情感气质。使用杨氏躁狂量表和蒙哥马利-阿斯伯格抑郁量表评估状态情绪症状。采用酶联免疫吸附测定法测量血清sICAM-1和sVCAM-1水平。
在调整混杂因素（年龄、性别、体重指数和吸烟习惯）后，检测到抑郁和易怒气质TEMPS-A评分与sVCAM-1水平之间存在高度负相关。虽然我们未发现sICAM-1水平与情感气质评分之间存在关联，但sICAM-1与躁狂症状的状态严重程度相关。在多元线性回归模型中，sVCAM-1仍然是抑郁气质评分而非易怒气质评分的显著预测因子。
气质是基于自我报告问卷进行评估的。
我们的研究结果表明，sVCAM-1与情感气质相关，是情绪障碍易感性的特质标志物。细胞黏附改变与情感气质之间的这种关系可能对情感障碍的易感性很重要。
