心血管疾病风险与重度抑郁症之间的关系
The Relationship Between Cardiovascular Disease Risk and Major Depression.
作者信息
Ozturk Bilge Targıtay, Ozel Fatih, Yaras Tutku, Ekinci Burcu, Oktay Yavuz, Aysevener Elif Onur, Alkın Tunc, Direk Neşe
机构信息
Department of Psychiatry, Dokuz Eylul University Medical School, Izmir, Turkey.
Department of Psychiatry, Izmir Cesme Alper Cizgenakat State Hospital, Izmir, Turkey.
出版信息
Noro Psikiyatr Ars. 2023 May 3;60(2):124-128. doi: 10.29399/npa.28191. eCollection 2023.
INTRODUCTION
Cardiovascular risk in depression has been investigated in small clinical samples and population-based studies revealing inconclusive results. However, cardiovascular risk in drug-naive depressed patients has not been tested extensively.
METHODS
Body mass index-based Framingham Cardiovascular Risk Scores and soluble intercellular adhesion molecule-1 (sICAM-1) levels were used to assess the risk of cardiovascular disease in drug-naive depressed patients and healthy volunteers.
CONCLUSION
There were no significant differences in Framingham Cardiovascular Risk Scores and individually assessed risk variables between patients and healthy controls (HC). Both groups were comparable in terms of sICAM-1.
RESULTS
The widely recognized association between cardiovascular risk and major depression might be more prominent in older depressed patients and patients with recurring episodes.
引言
在小型临床样本和基于人群的研究中对抑郁症患者的心血管风险进行了调查，结果尚无定论。然而，未服用过药物的抑郁症患者的心血管风险尚未得到广泛测试。
方法
使用基于体重指数的弗雷明汉心血管风险评分和可溶性细胞间黏附分子-1（sICAM-1）水平来评估未服用过药物的抑郁症患者和健康志愿者的心血管疾病风险。
结论
患者与健康对照（HC）之间在弗雷明汉心血管风险评分及单独评估的风险变量方面无显著差异。两组在sICAM-1方面具有可比性。
结果
心血管风险与重度抑郁症之间广泛认可的关联在老年抑郁症患者和复发发作患者中可能更为突出。
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