Karpathiou Georgia, Giroult Jean-Baptiste, Forest Fabien, Fournel Pierre, Monaya Alessandra, Froudarakis Marios, Dumollard Jean Marc, Prades Jean Michel, Gavid Marie, Peoc'h Michel
From the Department of Pathology.
Department of Head and Neck Surgery.
Am J Clin Pathol. 2016 Nov 1;146(5):546-553. doi: 10.1093/ajcp/aqw145.
Induction chemotherapy (IC) is occasionally used in head and neck cancer, leading to less extensive surgery and reduced need for irradiation. Factors predicting the response to IC have not been determined. In this study, we investigated the clinical and histopathologic factors that predict the response to IC.
Head and neck squamous cell carcinomas from 81 patients were analyzed; clinical factors, histologic parameters, and expression of p16 and p53 were correlated with response to chemotherapy and prognosis.
Factors predicting a good response to IC were the nonoropharyngeal localization, a rich lymphocytic tissue response, and a low platelet-to-lymphocyte blood ratio before treatment. Response to IC did not correlate with prognosis, whereas a low neutrophil-to-lymphocyte ratio (NLR), the absence of a desmoplastic reaction, a rich lymphocytic tissue response, and the overexpression of p53 were associated with better prognosis.
Lymphocytic tissue response, NLR, and nonoropharyngeal localization are factors predictive of response to IC.
诱导化疗（IC）偶尔用于头颈癌，可减少手术范围并降低放疗需求。预测IC反应的因素尚未确定。在本研究中，我们调查了预测IC反应的临床和组织病理学因素。
分析了81例患者的头颈鳞状细胞癌；临床因素、组织学参数以及p16和p53的表达与化疗反应和预后相关。
预测IC良好反应的因素为非口咽定位、丰富的淋巴细胞组织反应以及治疗前低血小板与淋巴细胞血比。IC反应与预后无关，而低中性粒细胞与淋巴细胞比（NLR）、无促结缔组织增生性反应、丰富的淋巴细胞组织反应以及p53过表达与较好预后相关。
淋巴细胞组织反应、NLR和非口咽定位是预测IC反应的因素。
