Nayyar R P, Oslapas R, Paloyan E
Research Service, Edward Hines, Jr., Veterans Administration Hospital, Hines, IL 60141.
J Exp Pathol. 1989;4(2):87-95.
The purpose of the present investigation was to determine whether there is a correlation between the serum levels of thyroid stimulating hormone (TSH), parafollicular cell (C) population in the thyroid and calcitonin (CT) secretion in aging Long-Evans (L-E) rats. Serum TSH and CT values were determined in 50 male rats at ages 2, 6, 12, 18 and 24 months and 50 female rats at 18, 21 and 24 months. The animals were sacrificed at the end of the experiment to evaluate thyroid C cell pathology. Male rats showed an increase in the serum TSH values at 6 and 12 months of age, a decline at 18 months and a significant increase from 18 to 24 months of age. In female rats, a significant increase in serum TSH concentration was also noted from 18 to 24 months of age. In both sexes, 24 month old animals with thyroid C cell hyperplasia (CH+ group) had a significantly higher level of serum TSH as compared to animals with normal distribution of C cells (CH- group). Concentration of serum CT showed a progressive increase with age in both sexes. Male rats with thyroid C cell pathology had significantly higher levels of serum CT at 24 months of age as compared to rats with normal C cell distribution. In female rats, however, serum CT concentrations in two groups were not statistically significant. We conclude from these studies that in aged L-E rats, serum TSH concentration has an influence on thyroid C cell population.
本研究的目的是确定衰老的长 Evans（L-E）大鼠血清促甲状腺激素（TSH）水平、甲状腺滤泡旁细胞（C 细胞）数量与降钙素（CT）分泌之间是否存在相关性。测定了 50 只 2、6、12、18 和 24 月龄雄性大鼠以及 50 只 18、21 和 24 月龄雌性大鼠的血清 TSH 和 CT 值。实验结束时处死动物以评估甲状腺 C 细胞病理学。雄性大鼠在 6 和 12 月龄时血清 TSH 值升高，18 月龄时下降，18 至 24 月龄时显著升高。雌性大鼠在 18 至 24 月龄时血清 TSH 浓度也显著升高。在两性中，与 C 细胞分布正常的动物（CH-组）相比，24 月龄甲状腺 C 细胞增生的动物（CH+组）血清 TSH 水平显著更高。血清 CT 浓度在两性中均随年龄逐渐升高。与 C 细胞分布正常的大鼠相比，24 月龄患有甲状腺 C 细胞病理学改变的雄性大鼠血清 CT 水平显著更高。然而，在雌性大鼠中，两组的血清 CT 浓度无统计学差异。我们从这些研究得出结论，在衰老的 L-E 大鼠中，血清 TSH 浓度对甲状腺 C 细胞数量有影响。
