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尿液干化学检测能否用于评估计划接受骨科手术患者的吸烟状况?一项前瞻性队列研究。

Can a urine dipstick test be used to assess smoking status in patients undergoing planned orthopaedic surgery? a prospective cohort study.

机构信息

Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, HA7 4LP, UK.

出版信息

Bone Joint J. 2016 Oct;98-B(10):1418-1424. doi: 10.1302/0301-620X.98B10.BJJ-2016-0303.R1.

Abstract

AIMS

Smoking is associated with post-operative complications but smokers often under-report the amount they smoke. Our objective was to determine whether a urine dipstick test could be used as a substitute for quantitative cotinine assays to determine smoking status in patients.

PATIENTS AND METHODS

Between September 2013 and July 2014 we conducted a prospective cohort study in which 127 consecutive patients undergoing a planned foot and ankle arthrodesis or osteotomy were included. Patients self-reported their smoking status and were classified as: 'never smoked' (61 patients), 'ex-smoker' (46 patients), or 'current smoker' (20 patients). Urine samples were analysed with cotinine assays and cotinine dipstick tests.

RESULTS

There was a high degree of concordance between dipstick and assay results (Kappa coefficient = 0.842, p < 0.001). Compared with the quantitative assay, the dipstick had a sensitivity of 88.9% and a specificity of 97.3%. Patients claiming to have stopped smoking just before surgery had the highest rate of disagreement between reported smoking status and urine testing.

CONCLUSION

Urine cotinine dipstick testing is cheap, fast, reliable, and easy to use. It may be used in place of a quantitative assay as a screening tool for detecting patients who may be smoking. A positive test may be used as a trigger for further assessment and counselling. Cite this article: Bone Joint J 2016;98-B:1418-24.

摘要

目的

吸烟与术后并发症相关,但吸烟者常少报吸烟量。我们的目的是确定尿试纸检测是否可替代定量可替宁检测来确定患者的吸烟状态。

患者和方法

2013 年 9 月至 2014 年 7 月,我们进行了一项前瞻性队列研究,纳入了 127 例连续行足部和踝关节融合术或截骨术的患者。患者自我报告吸烟状态,并分为:“从不吸烟”(61 例)、“已戒烟”(46 例)或“当前吸烟”(20 例)。用可替宁检测和可替宁试纸检测分析尿样。

结果

试纸与检测结果有高度一致性(Kappa 系数=0.842,p<0.001)。与定量检测相比,试纸检测的灵敏度为 88.9%,特异度为 97.3%。术前声称已戒烟的患者,其报告吸烟状态与尿检测之间的不一致率最高。

结论

尿可替宁试纸检测廉价、快速、可靠、易于使用。它可代替定量检测作为一种筛查工具,用于发现可能吸烟的患者。阳性检测结果可作为进一步评估和咨询的触发因素。

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