Finch P J, Fallowfield M E
St. George's Hospital Medical School, London, U.K.
J Pathol. 1989 Aug;158(4):297-301. doi: 10.1002/path.1711580406.
A novel method for grading intestinal metaplasia, with general applicability, is described. Highly significant agreement was found by kappa analysis both for intra-observer (k = 0.90) and for inter-observer (k = 0.85) variation, confirming the reproducibility of the method. The ranks derived by this method were correlated with gastric tissue levels of the enzymes beta-glucuronidase, lactic dehydrogenase (LDH), and %m-LDH. A significant (P less than 0.05) positive correlation was found between intestinal metaplasia and %m-LDH, but there was no correlation between intestinal metaplasia and beta-glucuronidase or LDH.
本文描述了一种具有普遍适用性的新型肠化生分级方法。通过kappa分析发现，观察者内变异（κ = 0.90）和观察者间变异（κ = 0.85）均具有高度显著的一致性，证实了该方法的可重复性。该方法得出的等级与胃组织中β-葡萄糖醛酸酶、乳酸脱氢酶（LDH）和%m-LDH的水平相关。肠化生与%m-LDH之间存在显著的（P < 0.05）正相关，但肠化生与β-葡萄糖醛酸酶或LDH之间无相关性。
