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老年医疗保险受益人群脆性骨折后骨质疏松症药物的使用情况。

Utilization of osteoporosis medication after a fragility fracture among elderly Medicare beneficiaries.

作者信息

Yusuf Akeem A, Matlon Thomas J, Grauer Andreas, Barron Richard, Chandler David, Peng Yi

机构信息

Amgen, Inc., Thousand Oaks, CA, USA.

College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.

出版信息

Arch Osteoporos. 2016 Dec;11(1):31. doi: 10.1007/s11657-016-0285-0. Epub 2016 Sep 30.

Abstract

UNLABELLED

Osteoporosis medications are recommended for elderly patients after a fragility fracture. However, we found substantial under-treatment in the post-fracture year, especially among patients who had not previously received such medications. Improved treatment of elderly patients experiencing fragility fractures is needed.

INTRODUCTION

Osteoporosis medications are recommended for elderly patients after a fragility fracture, but under-treatment is common. We determined osteoporosis medication use after fragility fractures and examined associated factors.

METHODS

Our cohort included elderly (age ≥66 years) Medicare-enrolled patients who sustained fragility fractures January 1, 2008-December 31, 2011. Osteoporosis medication prescriptions were determined in the 12 months after the index fracture. Using multivariate logistic models, we examined the association between post-fracture osteoporosis medication use and predictors.

RESULTS

Of 145,185 patients with fragility fractures (mean age 80.9 ± 7.8 years; 91.2 % white; 81.3 % female), 29.9 % sustained hip, 31.8 % vertebral, and 38.4 % non-hip-non-vertebral fractures. Overall, 30.4 % of the cohort received an osteoporosis medication in the 12-month post-fracture period. Of patients not receiving an osteoporosis medication in the pre-index period (n = 108,344), 14.9 % of all patients, 16.3 % of women, and 10.3 % of men received one in the post-fracture period. Corresponding values for patients receiving an osteoporosis medication in the pre-index period (n = 36,841) were 76.2, 76.5, and 72.2 %. Odds of post-fracture osteoporosis medication use were 68 % higher for women than for men. Osteoporosis diagnosis (odds ratio, 1.55; P < 0.0001) and bone-mineral-density tests before an index fracture (odds ratio, 1.24; P < 0.001) were associated with post-fracture osteoporosis medication use.

CONCLUSIONS

Less than one third of our cohort received an osteoporosis medication in the post-fracture year, when risk of a second fragility fracture is highest. In those not already previously treated with an osteoporosis medication, only about 1 in 7 patients received treatment.

摘要

未标注

骨质疏松症药物被推荐用于脆性骨折后的老年患者。然而,我们发现在骨折后的第一年治疗不足的情况很严重,尤其是在那些之前未接受过此类药物治疗的患者中。需要改善对发生脆性骨折的老年患者的治疗。

引言

骨质疏松症药物被推荐用于脆性骨折后的老年患者,但治疗不足很常见。我们确定了脆性骨折后骨质疏松症药物的使用情况并检查了相关因素。

方法

我们的队列包括2008年1月1日至2011年12月31日期间发生脆性骨折且参加医疗保险的老年(年龄≥66岁)患者。在初次骨折后的12个月内确定骨质疏松症药物处方。使用多变量逻辑模型,我们检查了骨折后骨质疏松症药物使用与预测因素之间的关联。

结果

在145,185例脆性骨折患者中(平均年龄80.9±7.8岁;91.2%为白人;81.3%为女性),29.9%发生髋部骨折,31.8%发生椎体骨折,38.4%发生非髋部非椎体骨折。总体而言,30.4%的队列在骨折后的12个月内接受了骨质疏松症药物治疗。在初次骨折前未接受骨质疏松症药物治疗的患者中(n = 108,344),所有患者中有14.9%、女性中有16.3%、男性中有10.3%在骨折后接受了一种药物治疗。初次骨折前接受骨质疏松症药物治疗的患者(n = 36,841)的相应比例分别为76.2%、76.5%和72.2%。骨折后使用骨质疏松症药物的几率女性比男性高68%。骨质疏松症诊断(比值比,1.55;P < 0.0001)和初次骨折前的骨密度测试(比值比,1.24;P < 0.001)与骨折后骨质疏松症药物使用相关。

结论

在我们的队列中,不到三分之一的患者在骨折后的一年接受了骨质疏松症药物治疗,而此时再次发生脆性骨折的风险最高。在那些之前未接受过骨质疏松症药物治疗的患者中,只有约七分之一的患者接受了治疗。

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