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Effects of cocaine self-administration history under limited and extended access conditions on in vivo striatal dopamine neurochemistry and acoustic startle in rhesus monkeys.在有限和延长获取条件下，可卡因自我给药史对恒河猴体内纹状体多巴胺神经化学及听觉惊吓反应的影响。
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9
Age- and sex-dependent amphetamine self-administration in rats.大鼠中年龄和性别依赖性的苯丙胺自我给药
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10
Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine.安非他命诱导的多巴胺释放：在可卡因依赖中显著减弱，并可预测自我给药可卡因的选择。
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低惊跳幅度可能是可卡因成瘾易感性的行为标志。

Low startle magnitude may be a behavioral marker of vulnerability to cocaine addiction.

作者信息

Wheeler Marina G, Duncan Erica, Davis Michael

机构信息

Department of Psychology, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322.

Yerkes National Primate Research Center, 954 Gatewood Road, NE Atlanta, Georgia, 30329.

出版信息

Synapse. 2017 Jan;71(1):46-50. doi: 10.1002/syn.21943. Epub 2016 Nov 18.

DOI:10.1002/syn.21943
PMID:27696533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5166556/
Abstract

Cocaine addicted men have low startle magnitude persisting during prolonged abstinence. Low startle rats show greater cocaine self-administration than high startle rats. Low startle may be a marker of a vulnerability to heightened cocaine-related behaviors in rats and similarly may be a marker of vulnerability to cocaine addiction in humans.

摘要

可卡因成瘾男性在长期禁欲期间惊吓反应幅度持续较低。低惊吓反应的大鼠比高惊吓反应的大鼠表现出更强的可卡因自我给药行为。低惊吓反应可能是大鼠中对与可卡因相关行为增强的易感性的一个标志，同样也可能是人类对可卡因成瘾易感性的一个标志。