新型抗癌剂：5-氨基-1,2-二氢-2-甲基-3-苯基吡啶并[3,4-b]吡嗪-7-氨基甲酸乙酯的手性异构体
New anticancer agents: chiral isomers of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7-car bamate .
作者信息
Temple C, Rener G A
机构信息
Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama 35255-5305.
出版信息
J Med Chem. 1989 Sep;32(9):2089-92. doi: 10.1021/jm00129a012.
PMID:2769680
Abstract
Racemic ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7- carbamate (1a) has shown antitumor activity in a variety of in vivo experiments. The preparation of the R and S isomers gave compounds with significant differences in potency in several biological tests.
摘要
消旋的5-氨基-1,2-二氢-2-甲基-3-苯基吡啶并[3,4-b]吡嗪-7-氨基甲酸乙酯（1a）在多种体内实验中已显示出抗肿瘤活性。R和S异构体的制备得到了在几种生物学试验中效力有显著差异的化合物。
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