Schlein Christian, Heeren Joerg
Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Best Pract Res Clin Endocrinol Metab. 2016 Aug;30(4):487-496. doi: 10.1016/j.beem.2016.08.002. Epub 2016 Aug 13.
Excess and ectopic fat accumulation in obesity is a major risk factor for developing hyperlipidemia, type 2 diabetes and cardiovascular disease. The activation of brown and/or beige adipocytes is a promising target for the treatment of metabolic disorders as the combustion of excess energy by these thermogenic adipocytes may help losing weight and improving plasma parameters including triglyceride, cholesterol and glucose levels. The regulation of heat production by thermogenic adipose tissues is based on a complex crosstalk between the autonomous nervous system, intracellular and secreted factors. This multifaceted alignment regulates thermogenic demands to environmental circumstances in dependence on available energy resources. This review summarizes the current knowledge how thermogenic tissues can be targeted to combat the burden of diseases with a special focus on lipid metabolism and diseases related to lipoprotein metabolism.
肥胖中过多的异位脂肪堆积是导致高脂血症、2型糖尿病和心血管疾病的主要危险因素。激活棕色和/或米色脂肪细胞是治疗代谢紊乱的一个有前景的靶点，因为这些产热脂肪细胞燃烧多余能量可能有助于减肥并改善血浆参数，包括甘油三酯、胆固醇和葡萄糖水平。产热脂肪组织的产热调节基于自主神经系统、细胞内和分泌因子之间复杂的相互作用。这种多方面的协调根据可用能源调节产热需求以适应环境情况。本综述总结了目前关于如何靶向产热组织以对抗疾病负担的知识，特别关注脂质代谢以及与脂蛋白代谢相关的疾病。
