Gupta Prachi, Bala Manju, Gupta Sanjeev, Dua Anita, Dabur Rajesh, Injeti Elisha, Mittal Ashwani
Skeletal Muscle Lab, University College, Kurukshetra University, Kurukshetra, Haryana, 136119, India.
Biochemistry Department, Maharshi Dayanand University, Rohtak, Haryana, 124001, India.
Pharmacol Res. 2016 Nov;113(Pt A):636-674. doi: 10.1016/j.phrs.2016.09.029. Epub 2016 Sep 30.
An increasing array of anti-diabetic drugs are available today, yet Type-2 diabetes mellitus (T2DM) - remains a life threatening disease, causing high mortality and morbidity in developing and developed countries. As of now, no effective therapy is available for the complete eradication/cure of diabetes and its associated complications. Therefore, it is time to re-think and revisit molecular pathways and targets of each existing drug in order to identify multiple targets from different signaling pathways that may be manipulated simultaneously to treat or manage T2DM effectively. Bearing this goal in mind, the article reviews the mechanisms of action of available anti-diabetic drugs with in-depth mechanistic analysis of each therapy. The conventional and herbal strategies are analysed and compared for their benefits and the associated possible side effects. This critical information is necessary not only for the development of better, novel and potent anti-diabetic therapy in future but also for best possible combinational therapies and strategies with the available drugs.
如今，抗糖尿病药物的种类越来越多，但2型糖尿病（T2DM）仍然是一种危及生命的疾病，在发展中国家和发达国家都导致了高死亡率和高发病率。截至目前，尚无有效的疗法可完全根除/治愈糖尿病及其相关并发症。因此，是时候重新思考并审视每种现有药物的分子途径和靶点了，以便从不同的信号通路中识别出多个靶点，这些靶点可以同时被操控以有效治疗或管理T2DM。牢记这一目标，本文回顾了现有抗糖尿病药物的作用机制，并对每种疗法进行了深入的机制分析。对传统策略和草药策略的益处及相关可能的副作用进行了分析和比较。这些关键信息不仅对于未来开发更好、新颖且有效的抗糖尿病疗法是必要的，而且对于使用现有药物进行最佳可能的联合疗法和策略也是必要的。
