首次发作精神病在注意力和记忆任务执行期间的功能磁共振成像关联
Functional Magnetic Resonance Imaging Correlates of First-Episode Psychoses during Attentional and Memory Task Performance.
作者信息
Del Casale Antonio, Kotzalidis Georgios D, Rapinesi Chiara, Sorice Serena, Girardi Nicoletta, Ferracuti Stefano, Girardi Paolo
机构信息
Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), School of Medicine and Psychology, Sapienza University, Rome, Italy.
出版信息
Neuropsychobiology. 2016;74(1):22-31. doi: 10.1159/000448620. Epub 2016 Oct 4.
BACKGROUND
The nature of the alteration of the response to cognitive tasks in first-episode psychosis (FEP) still awaits clarification. We used activation likelihood estimation, an increasingly used method in evaluating normal and pathological brain function, to identify activation changes in functional magnetic resonance imaging (fMRI) studies of FEP during attentional and memory tasks.
METHODS
We included 11 peer-reviewed fMRI studies assessing FEP patients versus healthy controls (HCs) during performance of attentional and memory tasks.
RESULTS
Our database comprised 290 patients with FEP, matched with 316 HCs. Between-group analyses showed that HCs, compared to FEP patients, exhibited hyperactivation of the right middle frontal gyrus (Brodmann area, BA, 9), right inferior parietal lobule (BA 40), and right insula (BA 13) during attentional task performances and hyperactivation of the left insula (BA 13) during memory task performances.
CONCLUSIONS
Right frontal, parietal, and insular dysfunction during attentional task performance and left insular dysfunction during memory task performance are significant neural functional FEP correlates.
背景
首发精神病（FEP）中认知任务反应改变的本质仍有待阐明。我们使用激活可能性估计（一种在评估正常和病理性脑功能中越来越常用的方法）来识别FEP患者在注意力和记忆任务的功能磁共振成像（fMRI）研究中的激活变化。
方法
我们纳入了11项经同行评审的fMRI研究，这些研究评估了FEP患者与健康对照（HC）在执行注意力和记忆任务时的情况。
结果
我们的数据库包括290名FEP患者，与316名HC相匹配。组间分析显示，与FEP患者相比，HC在执行注意力任务时右额中回（布罗德曼区，BA，9）、右下顶叶小叶（BA 40）和右岛叶（BA 13）表现为激活增强，在执行记忆任务时左岛叶（BA 13）激活增强。
结论
注意力任务执行期间右额叶、顶叶和岛叶功能障碍以及记忆任务执行期间左岛叶功能障碍是FEP重要的神经功能相关因素。
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