Zabrocka Ewa, Sierko Ewa, Jelski Stefan, Wojtukiewicz Marek Z
Department of Oncology, Medical University of Bialystok, 15-027 Bialystok, Poland.
Department of Oncology, Medical University of Bialystok, 15-027 Bialystok, Poland; Comprehensive Cancer Center in Bialystok, 15-027 Bialystok, Poland.
Mol Clin Oncol. 2016 Oct;5(4):455-457. doi: 10.3892/mco.2016.970. Epub 2016 Jul 27.
We herein report the case of a 74 year-old woman with a diffuse large B-cell lymphoma and bilateral renal masses identified on computed tomography scans during the initial staging process. Following partial bilateral nephrectomy, histopathological examination revealed renal cell carcinoma (RCC) and oncocytoma in the left and the right kidneys, respectively. Shortly afterwards, lymphoma of the left palatine tonsil was diagnosed and the patient received chemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP regimen), followed by radiotherapy. Due to metastasis of the RCC to the right breast, pancreas and the area of the left psoas major muscle, systemic treatment with pazopanib was commenced. To the best of our knowledge, this is the first reported case of simultaneous diagnosis of non-Hodgkin lymphoma (NHL), RCC and oncocytoma. The aim of this study was to review the related literature, discuss issues regarding the management of this unusual case and identify possible common etiopathological mechanisms underlying the simultaneous occurrence of NHL, RCC and oncocytoma.
我们在此报告一例74岁女性患者，在初始分期过程中经计算机断层扫描发现患有弥漫性大B细胞淋巴瘤及双侧肾脏肿块。双侧部分肾切除术后，组织病理学检查显示左肾为肾细胞癌（RCC），右肾为嗜酸细胞瘤。此后不久，左侧腭扁桃体淋巴瘤被诊断出来，患者接受了利妥昔单抗、环磷酰胺、阿霉素、长春新碱和泼尼松（R-CHOP方案）化疗，随后进行了放疗。由于肾细胞癌转移至右乳、胰腺及左腰大肌区域，开始使用帕唑帕尼进行全身治疗。据我们所知，这是首例同时诊断出非霍奇金淋巴瘤（NHL）、肾细胞癌和嗜酸细胞瘤的病例。本研究的目的是回顾相关文献，讨论该罕见病例的管理问题，并确定非霍奇金淋巴瘤、肾细胞癌和嗜酸细胞瘤同时发生可能的共同病因病理机制。
