HLA-E 限制性 T 细胞应答的特征及其在传染病中的作用。
Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases.
作者信息
Joosten Simone A, Sullivan Lucy C, Ottenhoff Tom H M
机构信息
Department of Infectious Diseases, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3010, Australia.
出版信息
J Immunol Res. 2016;2016:2695396. doi: 10.1155/2016/2695396. Epub 2016 Sep 6.
Human HLA-E can, in addition to self-antigens, also present pathogen-derived sequences, which elicit specific T-cell responses. T-cells recognize their antigen presented by HLA-E highly specifically and have unique functional and phenotypical properties. Pathogen specific HLA-E restricted CD8 T-cells are an interesting new player in the field of immunology. Future work should address their exact roles and relative contributions in the immune response against infectious diseases.
人类HLA-E除了能呈递自身抗原外，还能呈递病原体衍生的序列，从而引发特异性T细胞反应。T细胞能高度特异性地识别由HLA-E呈递的抗原，并具有独特的功能和表型特性。病原体特异性的HLA-E限制性CD8 T细胞是免疫学领域一个有趣的新成员。未来的研究应探讨它们在针对传染病的免疫反应中的确切作用和相对贡献。
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