描述糖类对C型和D型肉毒杆菌毒素复合物血凝抑制特性的数据。
Data describing inhibitory profiles of sugars against hemagglutination by the botulinum toxin complex of serotypes C and D.
作者信息
Sagane Yoshimasa, Ito Minoru, Miyata Keita, Suzuki Tomonori, Niwa Koichi, Oguri Suguru, Watanabe Toshihiro
机构信息
Department of Food and Cosmetic Science, Faculty of Bioindustry, Tokyo University of Agriculture, 196 Yasaka, Abashiri 099-2493, Japan.
Groupwide Research and Development, Noevir Co., Ltd., 112-1, Okadacho, Higashiohmi 527-8588, Japan.
出版信息
Data Brief. 2016 Sep 17;9:413-416. doi: 10.1016/j.dib.2016.09.014. eCollection 2016 Dec.
Serotype C and D of produce botulinum toxin complex (TC), which is comprised of botulinum neurotoxin, nontoxic nonhemagglutinin, and hemagglutinins (HAs). The TC is capable of aggregating equine erythrocytes via interaction between one of the HAs, namely HA-33, and sugar chains on the cell surface. This hemagglutination is inhibited by specific sugars. In this data article, we used four TCs from serotype C and D strains. The hemagglutination-inhibiting effects of 18 sugars and 8 glycoproteins were studied. The purified TC was mixed with the sugar to enable binding of the sugar to the TC; then, the erythrocytes were added to the mixture. Specific binding between the sugar and TC resulted in inhibition of cell aggregation. Here, data illustrating the inhibitory effects of various sugars and glycoproteins against hemagglutination induced by TC of serotypes C and D are presented.
C型和D型菌株产生肉毒杆菌毒素复合物（TC），该复合物由肉毒杆菌神经毒素、无毒非血凝素和血凝素（HAs）组成。TC能够通过其中一种血凝素（即HA-33）与细胞表面糖链之间的相互作用使马红细胞聚集。这种血凝反应可被特定糖类抑制。在这篇数据文章中，我们使用了来自C型和D型菌株的四种TC。研究了18种糖类和8种糖蛋白的血凝抑制作用。将纯化的TC与糖类混合，使糖类与TC结合；然后，将红细胞加入混合物中。糖类与TC之间的特异性结合导致细胞聚集受到抑制。在此，展示了各种糖类和糖蛋白对C型和D型菌株TC诱导的血凝反应的抑制作用的数据。
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