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M2 macrophages do not fly into a "RAGE".

作者信息

Rojas Armando, Añazco Carolina, Araya Paulina

机构信息

Biomedical Research Laboratories, Medicine Faculty, Catholic University of Maule, 3605 San Miguel Ave., Talca, Chile.

出版信息

Inflamm Res. 2017 Jan;66(1):13-15. doi: 10.1007/s00011-016-0994-2. Epub 2016 Oct 3.

DOI:10.1007/s00011-016-0994-2
PMID:27699448
Abstract

Tumor-associated macrophages (TAMs) are key elements in orchestrating host responses inside tumor stroma. This population may undergo a polarized activation process, thus rendering a heterogeneous spectrum of phenotypes, where the classically activated type 1 macrophages (M1) and the alternative activated type 2 macrophages (M2) represent two extreme phenotypes. In this commentary, based on very recent research findings, we intend to highlight how complex could be the crosstalk among all components of tumor stroma, where the coexistence of non-natural partners may even skew the canonical responses that we can expect.

摘要

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本文引用的文献

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Pharmacol Ther. 2016 Dec;168:61-74. doi: 10.1016/j.pharmthera.2016.09.002. Epub 2016 Sep 2.
2
Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages.肿瘤缺氧通过高迁移率族蛋白 B1 和 M2 样巨噬细胞促进黑色素瘤生长和转移。
Sci Rep. 2016 Jul 18;6:29914. doi: 10.1038/srep29914.
3
Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy.
肿瘤相关巨噬细胞：抗肿瘤治疗的潜在治疗靶点。
Adv Drug Deliv Rev. 2016 Apr 1;99(Pt B):180-185. doi: 10.1016/j.addr.2015.11.009. Epub 2015 Nov 24.
4
Extracellular matrix component signaling in cancer.细胞外基质成分在癌症中的信号传递。
Adv Drug Deliv Rev. 2016 Feb 1;97:28-40. doi: 10.1016/j.addr.2015.10.013. Epub 2015 Oct 28.
5
HMGB1 enhances the protumoral activities of M2 macrophages by a RAGE-dependent mechanism.高迁移率族蛋白B1（HMGB1）通过一种依赖于晚期糖基化终末产物受体（RAGE）的机制增强M2巨噬细胞的促肿瘤活性。
Tumour Biol. 2016 Mar;37(3):3321-9. doi: 10.1007/s13277-015-3940-y. Epub 2015 Oct 6.
6
Study of the activated macrophage transcriptome.活化巨噬细胞转录组的研究。
Exp Mol Pathol. 2015 Dec;99(3):575-80. doi: 10.1016/j.yexmp.2015.09.014. Epub 2015 Oct 9.
7
Integrated Transcriptomics Establish Macrophage Polarization Signatures and have Potential Applications for Clinical Health and Disease.整合转录组学确定巨噬细胞极化特征并在临床健康与疾病方面具有潜在应用。
Sci Rep. 2015 Aug 25;5:13351. doi: 10.1038/srep13351.
8
Macrophage development and polarization in chronic inflammation.慢性炎症中巨噬细胞的发育与极化
Semin Immunol. 2015 Aug;27(4):257-66. doi: 10.1016/j.smim.2015.07.002. Epub 2015 Jul 26.
9
Macrophage polarization in pathology.病理学中的巨噬细胞极化
Cell Mol Life Sci. 2015 Nov;72(21):4111-26. doi: 10.1007/s00018-015-1995-y. Epub 2015 Jul 26.
10
Tumor-associated macrophages as an emerging target against tumors: Creating a new path from bench to bedside.肿瘤相关巨噬细胞作为一种新兴的抗肿瘤靶点：开创从 bench 到 bedside 的新路径 。 （注：这里“bench”直译为“实验台”，“bedside”直译为“床边”，在医学领域常用来表示从基础研究到临床应用的过程，可意译为从实验室研究到临床实践 ）
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