Wollenberg Barbara
Department of Otorhinolaryngology, University of Schleswig-Holstein Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.
Recent Results Cancer Res. 2017;206:243-248. doi: 10.1007/978-3-319-43580-0_19.
HNSCC is a heterogeneous group of tumors located in the oral cavity, oropharynx, hypopharynx and larynx. Originally, tobacco and alcohol exposures were the main risk factors for HNSCC. In the last two decades, HPV infections have been identified as a risk factor for HNSCC, especially for oropharyngeal tumors. Whereas the HPV-induced oropharyngeal carcinomas predominantly express the HPV16 related E6 and E7 oncoproteins, the HPV-negative HNSCC are associated with an overexpression of p53. However, if the therapy successes for HPV-negative and HPV-positive HNSCCs are compared, there are significantly higher total survival rates for HPV-positive oropharyngeal tumors compared to HPV-negative tumors. It is important to understand this phenomenon in order to improve and adapt therapy concepts.
头颈部鳞状细胞癌（HNSCC）是一组异质性肿瘤，位于口腔、口咽、下咽和喉部。最初，烟草和酒精暴露是HNSCC的主要危险因素。在过去二十年中，人乳头瘤病毒（HPV）感染已被确定为HNSCC的一个危险因素，尤其是口咽肿瘤。HPV诱导的口咽癌主要表达与HPV16相关的E6和E7癌蛋白，而HPV阴性的HNSCC与p53的过表达有关。然而，如果比较HPV阴性和HPV阳性HNSCC的治疗成功率，HPV阳性口咽肿瘤的总生存率明显高于HPV阴性肿瘤。了解这一现象对于改进和调整治疗方案很重要。
