Ito K, Murakami S, Oku N, Takeda N, Shimazaki C, Nakanishi S, Nishio A, Haruyama H, Nakagawa M, Fujita N
Rinsho Ketsueki. 1989 Apr;30(4):558-62.
A 56-year-old female, who was diagnosed as CML in 1983 and had been well controlled with busulfan, was admitted to our hospital because of fever and iliac bone pain. Peripheral blood showed leukocytosis (WBC 70,000/microliters and bone marrow was normocellular with 53% leukemic cells, suggesting that she was in the blastic crisis. Chromosomal analysis of bone marrow cells at that time revealed t (9; 22; 12) and some additional abnormalities. The number of chromosomes ranged from 44 to 131 and the mode of chromosome number was 65. She was treated with combination regimen consisting of vincristine, 6-mercaptopurine and prednisolone and right iliac tumor was irradiated. Three months after admission, she died of DIC and pulmonary insufficiency due to leukemic infiltration.
一名56岁女性，1983年被诊断为慢性粒细胞白血病，一直使用白消安控制良好，因发热和髂骨疼痛入院。外周血显示白细胞增多（白细胞计数70,000/微升），骨髓细胞正常，但白血病细胞占53%，提示处于急变期。当时对骨髓细胞进行染色体分析显示t(9;22;12)及一些其他异常。染色体数目在44至131之间，众数为65。她接受了长春新碱、6-巯基嘌呤和泼尼松龙联合方案治疗，并对右侧髂骨肿瘤进行了放疗。入院三个月后，她死于弥散性血管内凝血和白血病浸润导致的肺功能不全。
