Sugino H, Shimada H
Department of Clinical Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Jpn J Pharmacol. 1989 Jun;50(2):239-42. doi: 10.1254/jjp.50.239.
The effects of diltiazem on plasma uric acid level (PUA) and renal uric acid excretion were investigated in oxonate-loaded rats. Diltiazem (0.5 mg/kg, i.v.) decreased PUA without producing uricosuria, and it decreased fractional excretion of uric acid and renal blood flow. The present results suggest that diltiazem produces hypouricemia not accompanied by uricosuria, probably by affecting uric acid metabolism, and it may also cause an alteration in the renal handling of uric acid partly due to changes in renal hemodynamics.
在氧嗪酸钾负荷大鼠中研究了地尔硫䓬对血浆尿酸水平（PUA）和肾脏尿酸排泄的影响。地尔硫䓬（0.5毫克/千克，静脉注射）降低了PUA，但未产生尿酸尿，并且它降低了尿酸分数排泄和肾血流量。目前的结果表明，地尔硫䓬产生不伴有尿酸尿的低尿酸血症，可能是通过影响尿酸代谢，并且它也可能部分由于肾血流动力学的变化而导致肾脏对尿酸的处理发生改变。
