加用米氮平可改善使用第一代抗精神病药物治疗的精神分裂症患者的性高潮功能。
Add-on mirtazapine improves orgasmic functioning in patients with schizophrenia treated with first-generation antipsychotics.
作者信息
Terevnikov Viacheslav, Stenberg Jan-Henry, Tiihonen Jari, Burkin Mark, Joffe Grigori
机构信息
a Kellokoski Hospital, Kellokoski, and University of Helsinki , Finland.
b Department of Psychiatry , Helsinki University Central Hospital, and University of Helsinki , Helsinki , Finland.
出版信息
Nord J Psychiatry. 2017 Jan;71(1):77-80. doi: 10.1080/08039488.2016.1233996. Epub 2016 Oct 5.
AIM
Sexual dysfunction, common in schizophrenia, may be further exaggerated by antipsychotics, especially those of First Generation (FGAs), and antidepressants, such as Selective Serotonin Reuptake Inhibitors (SSRs). Mirtazapine, an antidepressant characterized by its different action mechanism compared with that of the majority of other antidepressants, may improve SSRI-induced sexual dysfunction in patients with depression. It is unknown, however, whether mirtazapine improves sexual functioning in schizophrenia.
METHODS
This study randomly assigned FGA-treated patients with schizophrenia to receive either an add-on mirtazapine (n = 20) or a placebo (n = 19) for 6 weeks. Sexual functioning was prospectively measured using five relevant items from the Udvalg for Kliniske Undersogelser side-effect rating scale (UKU-SERS).
RESULTS
Orgasmic function improved with statistical significance in the mirtazapine group (p = .03), with no changes in any other sexual functions in either group.
CONCLUSION
Add-on mirtazapine appears to relieve orgasmic dysfunction in FGA-treated patients with schizophrenia.
目的
性功能障碍在精神分裂症中很常见，可能会被抗精神病药物（尤其是第一代抗精神病药物）和抗抑郁药（如选择性5-羟色胺再摄取抑制剂）进一步加重。米氮平是一种抗抑郁药，其作用机制与大多数其他抗抑郁药不同，可能会改善抑郁症患者中由选择性5-羟色胺再摄取抑制剂引起的性功能障碍。然而，尚不清楚米氮平是否能改善精神分裂症患者的性功能。
方法
本研究将接受第一代抗精神病药物治疗的精神分裂症患者随机分为两组，一组加用米氮平（n = 20），另一组加用安慰剂（n = 19），为期6周。使用临床检查副作用评定量表（UKU-SERS）中的五项相关指标对性功能进行前瞻性测量。
结果
米氮平组的性高潮功能有统计学意义的改善（p = 0.03），两组的其他性功能均无变化。
结论
加用米氮平似乎可以缓解接受第一代抗精神病药物治疗的精神分裂症患者的性高潮功能障碍。
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