与维生素B12缺乏相关的可逆性面部色素沉着

Reversible Facial Hyperpigmentation Associated With Vitamin B12 Deficiency.

作者信息

Tayem Leeda, Litaiem Noureddine, Jones Mariem, Zeglaoui Faten

机构信息

1 Department of Dermatology, Charles Nicolle Hospital, University of Tunis El Manar, Tunis, Tunisia.

出版信息

Nutr Clin Pract. 2017 Apr;32(2):275-276. doi: 10.1177/0884533616670380. Epub 2016 Oct 5.

DOI:10.1177/0884533616670380

PMID:27702910

Abstract

Vitamin B12 (cobalamin) deficiency is common in developing countries. Its dermatologic manifestations include hair and nail changes and glossitis. Cases of generalized hyperpigmentation associated with vitamin B12 deficiency have rarely been reported. Localized hyperpigmentation is less frequently described, affecting palms, soles, and flexural areas. We report a rare case of reversible melasma-like cutaneous hyperpigmentation associated with pernicious anemia and discuss the possible mechanisms of this association.

摘要

维生素B12（钴胺素）缺乏在发展中国家很常见。其皮肤表现包括毛发和指甲变化以及舌炎。与维生素B12缺乏相关的全身性色素沉着病例鲜有报道。局限性色素沉着的描述较少，累及手掌、足底和屈侧部位。我们报告一例与恶性贫血相关的可逆性黄褐斑样皮肤色素沉着罕见病例，并讨论这种关联的可能机制。