Ritenbaugh C, Goodby C S
Med Anthropol. 1989 Jun;11(3):227-36. doi: 10.1080/01459740.1989.9965995.
Several models have been proposed to explain the high prevalence of non-insulin dependent diabetes mellitus (NIDDM) and other diseases among New World populations. This paper examines the implications of a northern hunting adaptation (reliance on animal foods, seasonal shortages) in terms of energy digestion, absorption, metabolism and storage. Physiologic adaptations to a high protein, moderate fat, low carbohydrate diet are then examined in the context of agriculturally-based subsistence systems and in industrialized societies. Specific metabolic pathways, consistent with the work of both Neel and Weiss, are identified as fruitful areas for further research regarding genetic variants in New World populations.
已经提出了几种模型来解释非胰岛素依赖型糖尿病（NIDDM）和其他疾病在新大陆人群中的高患病率。本文从能量消化、吸收、代谢和储存的角度研究了北方狩猎适应方式（依赖动物性食物、季节性短缺）的影响。然后，在以农业为基础的生存系统和工业化社会的背景下，研究了对高蛋白、适度脂肪、低碳水化合物饮食的生理适应。与尼尔和魏斯的研究成果一致的特定代谢途径，被确定为新大陆人群基因变异进一步研究的富有成果的领域。
