Fernández-Gutiérrez Mar, Rodriguez-Mancheño Marta, Pérez-Köhler Bárbara, Pascual Gemma, Bellón Juan Manuel, Román Julio San
Instituto de Ciencia y Tecnología de Polímeros, CSIC Juan de la Cierva 3, 28006, Madrid, Spain.
CIBER-BBN Instituto de Salud Carlos III, 28029, Madrid, Spain.
Macromol Biosci. 2016 Dec;16(12):1803-1814. doi: 10.1002/mabi.201600246. Epub 2016 Oct 5.
The article deals with a comparative analysis of the parameters of the polymerization in physiological conditions of three commercially available alkyl cyanoacrylates, n-butyl cyanoacrylate (GLUBRAN 2), n-hexyl cyanoacrylate (IFABOND), and n-octyl cyanoacrylate (EVOBOND), the cell behavior of the corresponding polymers and the application of these adhesives in the fixation of surgical polypropylene meshes for hernia repair in an animal model of rabbits. The results obtained demonstrate that the curing process depends on the nature of the alkyl residue of the ester group of cyanoacrylate molecules, being the heat of polymerization lower for the octyl derivative in comparison with the hexyl and butyl, and reaching a maximum temperature of 35 °C after a time of mixing with physiological fluids of 60-70 s. The cell behavior demonstrates that the three systems do not present toxicity for fibroblasts and low adhesion of cells, which is a positive result for application as tissue adhesives, especially for the fixation of abdominal polypropylene meshes for hernia repair. The animal experimentation indicates the excellent tolerance of the meshes fixed with the cyanoacrylic adhesives, during at least a period of 90 d, and guarantees a good adhesion for the application of hernia repair meshes.
本文对三种市售氰基丙烯酸烷基酯（正丁基氰基丙烯酸酯（GLUBRAN 2）、正己基氰基丙烯酸酯（IFABOND）和正辛基氰基丙烯酸酯（EVOBOND））在生理条件下的聚合参数、相应聚合物的细胞行为以及这些粘合剂在兔动物模型中用于疝修补手术聚丙烯网片固定的应用进行了比较分析。所得结果表明，固化过程取决于氰基丙烯酸酯分子酯基烷基残基的性质，与己基和丁基衍生物相比，辛基衍生物的聚合热较低，与生理流体混合60 - 70秒后达到最高温度35°C。细胞行为表明，这三种体系对成纤维细胞无毒性且细胞粘附性低，这对于作为组织粘合剂应用，特别是用于疝修补的腹部聚丙烯网片固定来说是一个积极的结果。动物实验表明，用氰基丙烯酸粘合剂固定的网片至少在90天内具有良好的耐受性，并保证了疝修补网片应用时的良好粘附性。
