金黄色葡萄球菌的SaeRS双组分系统
The SaeRS Two-Component System of Staphylococcus aureus.
作者信息
Liu Qian, Yeo Won-Sik, Bae Taeok
机构信息
Department of Laboratory Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Department of Microbiology and Immunology, Indiana University School of Medicine-Northwest, Gary, IN 46408, USA.
出版信息
Genes (Basel). 2016 Oct 3;7(10):81. doi: 10.3390/genes7100081.
In the Gram-positive pathogenic bacterium Staphylococcus aureus, the SaeRS twocomponent system (TCS) plays a major role in controlling the production of over 20 virulence factors including hemolysins, leukocidins, superantigens, surface proteins, and proteases. The SaeRS TCS is composed of the sensor histidine kinase SaeS, response regulator SaeR, and two auxiliary proteins SaeP and SaeQ. Since its discovery in 1994, the sae locus has been studied extensively, and its contributions to staphylococcal virulence and pathogenesis have been well documented and understood; however, the molecular mechanism by which the SaeRS TCS receives and processes cognate signals is not. In this article, therefore, we review the literature focusing on the signaling mechanism and its interaction with other global regulators.
在革兰氏阳性病原菌金黄色葡萄球菌中，双组分系统SaeRS在控制20多种毒力因子的产生中起主要作用，这些毒力因子包括溶血素、杀白细胞素、超抗原、表面蛋白和蛋白酶。SaeRS双组分系统由传感组氨酸激酶SaeS、反应调节因子SaeR以及两个辅助蛋白SaeP和SaeQ组成。自1994年发现sae基因座以来，人们对其进行了广泛研究，并且其对葡萄球菌毒力和发病机制的作用已有充分记载和了解；然而，SaeRS双组分系统接收和处理同源信号的分子机制尚不清楚。因此，在本文中，我们回顾了聚焦于信号传导机制及其与其他全局调节因子相互作用的文献。
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