Brás Luís P, Luís Ângelo, Chatel Gregory, Socorro Sílvia, Duarte Ana Paula
RISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.
EDYTEM, CNRS, University Savoie Mont Blanc, F-73000 Chambéry, France.
Int J Mol Sci. 2025 Aug 26;26(17):8269. doi: 10.3390/ijms26178269.
The wine industry represents a significant economic sector; however, it generates large volumes of waste that can be valorized due to the presence of bioactive compounds, particularly stilbenes. These naturally occurring stilbenes exhibit remarkable potential in the prevention and treatment of various diseases, including cardioprotection, neuroprotection, antidiabetic properties, anti-inflammatory activity, and cancer prevention and therapy. This review discusses biosynthesis, structures, extraction methods, and mechanisms of action of stilbenes, with a particular emphasis on cancer prevention and treatment. Evidence from in vitro, in vivo, and clinical studies demonstrate that stilbenes modulate multiple molecular pathways by promoting apoptosis, inhibiting cell proliferation, and regulating inflammation, oxidative stress, and metabolism. However, the clinical application of stilbenes is limited by their low bioavailability. To overcome this, pharmaceutical formulations have been developed to enhance their stability and bioavailability, reduce side effects, and improve target interactions. These advances are expected to increase the therapeutic efficacy of stilbenes. Furthermore, information on the health benefits of less common stilbenes remains limited, highlighting the need for further research on these compounds.
葡萄酒产业是一个重要的经济部门；然而，它会产生大量的废弃物，由于其中存在生物活性化合物，特别是芪类化合物，这些废弃物可以得到有效利用。这些天然存在的芪类化合物在预防和治疗各种疾病方面具有显著潜力，包括心脏保护、神经保护、抗糖尿病特性、抗炎活性以及癌症预防和治疗。本综述讨论了芪类化合物的生物合成、结构、提取方法和作用机制，特别强调了癌症预防和治疗。来自体外、体内和临床研究的证据表明，芪类化合物通过促进细胞凋亡、抑制细胞增殖以及调节炎症、氧化应激和代谢来调节多种分子途径。然而，芪类化合物的临床应用受到其低生物利用度的限制。为了克服这一问题，已经开发了药物制剂来提高其稳定性和生物利用度，减少副作用，并改善靶点相互作用。这些进展有望提高芪类化合物的治疗效果。此外，关于不太常见的芪类化合物对健康益处的信息仍然有限，这突出了对这些化合物进行进一步研究的必要性。
