Akhmenov N A, Abbasly P M, Popov E M
Mol Biol (Mosk). 1989 May-Jun;23(3):676-82.
Theoretical conformational analysis was carried out for a nonapeptide hormone (delta sleep-inducing peptide). Possible structure of the neuropeptide under physiological conditions may be described by a set of low-energy conformations belonging to nine different forms of the backbone. A solution of the "reverse conformational problem" for delta sleep inducing peptide enables one to predict modified amino acid sequences (D-Ala3-, Pro4-, Pro6-, Pro7, and Tyr7-analogs), which may assume one of the low-energy states of the native hormone. The influence of the solute was not taken into account in our calculations.
对一种九肽激素（δ-睡眠诱导肽）进行了理论构象分析。该神经肽在生理条件下的可能结构可以通过一组属于主链九种不同形式的低能量构象来描述。解决δ-睡眠诱导肽的“反向构象问题”，能够预测修饰的氨基酸序列（D-Ala3-、Pro4-、Pro6-、Pro7-和Tyr7-类似物），这些序列可能呈现天然激素的低能量状态之一。我们的计算中未考虑溶质的影响。
