Lelic Alina, Verschoor Chris P, Lau Vivian W C, Parsons Robin, Evelegh Carole, Bowdish Dawn M, Bramson Jonathan L, Loeb Mark B
Department of Pathology and Molecular Medicine.
Canadian Longitudinal Study on Aging.
J Infect Dis. 2016 Dec 15;214(12):1905-1910. doi: 10.1093/infdis/jiw462. Epub 2016 Oct 5.
Little is known about the immunogenicity of live-attenuated Oka/Merck varicella zoster virus (VZV)-containing vaccine (hereafter, "varicella vaccine") in frail nursing homes residents nor about immune phenotypes associated with a response.
A cohort of 190 frail nursing home residents aged 80-102 years and a cohort of 50 community-dwelling seniors aged 60-75 years (a comparison group) received varicella vaccine. Interferon γ (IFN-γ) enzyme-linked immunospot assays were performed before and 6 weeks after vaccination. Cellular markers of immunosenescence were measured in the nursing home elderly.
The average number of IFN-γ spot-forming cells at baseline was significantly lower in the elderly nursing home residents than in the community-dwelling seniors. However, following vaccination, the VZV immune response increased in both cohorts, and no difference was noted in the fold difference of the response between the 2 cohorts. Upon further examination of the elderly nursing home residents, we found that higher frequencies of regulatory T cells and cytomegalovirus-specific CD4 T cells correlated negatively with the magnitude of VZV-specific responses.
The Oka/Merck varicella vaccine induces VZV immunity in elderly nursing home residents that is similar to that produced in community-dwelling seniors.
NCT01328548.
关于含减毒活Oka/默克水痘带状疱疹病毒（VZV）疫苗（以下简称“水痘疫苗”）在体弱的养老院居民中的免疫原性，以及与免疫反应相关的免疫表型，人们了解甚少。
190名年龄在80 - 102岁的体弱养老院居民和50名年龄在60 - 75岁的社区老年人（对照组）接种了水痘疫苗。在接种疫苗前和接种后6周进行干扰素γ（IFN - γ）酶联免疫斑点试验。对养老院老年人的免疫衰老细胞标志物进行了检测。
养老院老年居民基线时IFN - γ斑点形成细胞的平均数量显著低于社区老年人。然而，接种疫苗后，两个队列的VZV免疫反应均增强，且两个队列之间反应的倍数差异无显著差异。在对养老院老年居民进一步检查时，我们发现调节性T细胞和巨细胞病毒特异性CD4 T细胞的较高频率与VZV特异性反应的强度呈负相关。
Oka/默克水痘疫苗在养老院老年居民中诱导的VZV免疫力与社区老年人相似。
NCT01328548。
