Murphy S, Davis J L, Walsh P N, Gardner F H
Arch Intern Med. 1978 Aug;138(8):1251-3.
In 32 patients with myeloproliferative disorders (MPD), correlations were made among clinical observations of hemorrhagic tendency, template Ivy bleeding time, and platelet aggregation studies. Bleeding time was commonly prolonged, particularly in myelofibrosis. In two cases, this prolongation appeared to reflect a defect in platelet function, which resulted in clinical bleeding. Prolongation of bleeding time did not correlate with degree of thrombocytosis. Two patients with thrombocytosis had serious clinical bleeding at a time when bleeding time was normal. Of the patients, 35% had abnormal findings from aggregation studies, but there was no correlation between aggregation studies and prolongation of bleeding time or clinical hemorrhage. We conclude that bleeding in MPD arises either from a defect in platelet function, which is reflected in a prolonged bleeding time, or from thrombocytosis.
在32例骨髓增殖性疾病（MPD）患者中，对出血倾向的临床观察、模板式艾维出血时间及血小板聚集研究进行了相关性分析。出血时间通常延长，尤其是在骨髓纤维化患者中。有2例患者，这种延长似乎反映了血小板功能缺陷，进而导致临床出血。出血时间延长与血小板增多程度无关。2例血小板增多患者在出血时间正常时发生了严重的临床出血。在这些患者中，35%的患者聚集研究结果异常，但聚集研究与出血时间延长或临床出血之间无相关性。我们得出结论，MPD患者的出血要么源于血小板功能缺陷（表现为出血时间延长），要么源于血小板增多。
