Komissarov I V, Abramets I I, Samoĭlovich I M
Neirofiziologiia. 1989;21(3):352-7.
Tryptamine has been studied for its effect on the 5-hydroxytryptamine-induced responses of the dorsal root ganglion neurons in rat with intracellular registration of the membrane potential and conductance and application of drugs from micropipettes under pressure. It was found that tryptamine applied in high concentrations acted like 5-hydroxytryptamine; but in the concentration range when it has no effect on the membrane potential and membrane conductance it either enhanced (10(-7) mol/l) or diminished (10(-5) mol/l) 5-hydroxytryptamine responses mediated by 5-HT1A- but not by 5-HT2-receptors. Harmane acted like tryptamine, but its derivatives either only enhanced or only inhibited the 5-hydroxytryptamine effects. The allosterical nature of 5-hydroxytryptamine-modulating action of tryptamine, harmane and its derivatives is discussed.
利用膜电位和电导的细胞内记录技术以及在压力下通过微量移液器给药的方法，研究了色胺对大鼠背根神经节神经元5-羟色胺诱导反应的影响。结果发现，高浓度的色胺作用类似于5-羟色胺；但在对膜电位和膜电导无影响的浓度范围内，它要么增强（10⁻⁷mol/L）要么减弱（10⁻⁵mol/L）由5-HT1A受体而非5-HT2受体介导的5-羟色胺反应。哈尔满的作用类似于色胺，但其衍生物要么仅增强要么仅抑制5-羟色胺的作用。文中讨论了色胺、哈尔满及其衍生物对5-羟色胺调节作用的变构性质。
