Douglas Abby P, Slavin Monica A
a Department of Infectious Diseases , Peter MacCallum Cancer Centre , Melbourne , VIC , Australia.
b Victorian Infectious Diseases Service , Royal Melbourne Hospital , Melbourne , VIC , Australia.
Expert Rev Anti Infect Ther. 2016 Dec;14(12):1165-1177. doi: 10.1080/14787210.2016.1245613. Epub 2016 Oct 22.
Due to increasing intensity and complexity of therapies and longer survivorship, many patients with haematologic malignancy (HM) are at risk of invasive fungal disease (IFD). Mortality from IFD is high and treatment of an episode of IFD results in an excess length of hospital stay and costs and delays delivery of curative therapy of the underlying haematologic condition. Therefore, prevention and early recognition and treatment of IFD are crucial. Areas covered: Risk factors particular to certain HMs and haematopoietic stem cell transplantation, as well as those risk factors universal to all HM groups are examined. Expert commentary: Risk stratification identifies those patients who would benefit most from mould active versus yeast active prophylaxis and those who can be safely managed with monitoring and clinically driven interventions for IFD. This approach aids in antifungal stewardship.
由于治疗强度和复杂性不断增加以及生存期延长，许多血液系统恶性肿瘤（HM）患者面临侵袭性真菌病（IFD）的风险。IFD导致的死亡率很高，治疗IFD会导致住院时间延长、费用增加，并延误潜在血液系统疾病的根治性治疗。因此，IFD的预防、早期识别和治疗至关重要。涵盖领域：研究了某些血液系统恶性肿瘤和造血干细胞移植特有的危险因素，以及所有血液系统恶性肿瘤组共有的危险因素。专家评论：风险分层可确定哪些患者从预防霉菌活性与预防酵母活性中获益最大，以及哪些患者可以通过监测和针对IFD的临床驱动干预措施进行安全管理。这种方法有助于抗真菌管理。
