a Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Centre , Shanghai Jiao Tong University School of Medicine , Shanghai , P.R. China.
b Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Centre for Brain Science , Shanghai Jiao Tong University , Shanghai , P.R. China.
World J Biol Psychiatry. 2017 Oct;18(7):550-556. doi: 10.1080/15622975.2016.1245442. Epub 2016 Nov 16.
The ATP-binding cassette transporter superfamily is one of the largest membrane protein families, which is responsible for transportation of substances across the membranes by utilising energy. Some research has bridged the variations in ABCA13 with occurrence of psychiatric disorders. To investigate the overlapping risk conferred by ABCA13 for both major depressive disorder and schizophrenia, we analysed tag single nucleotide polymorphisms (tag SNPs).
We used TaqMan technology to genotype 1045 major depressive disorder patients, 1235 schizophrenia patients and 1235 healthy controls of Han Chinese origin.
We found that rs7789493 (P=7.23E-04, P=.001) was associated with major depressive disorder, while rs17132388 (P=1.63E-04, P=7.50E-04) and rs6583476 (P=5.50E-04, P=.002) showed statistically significant association with schizophrenia.
Our results indicate that the ABCA13 gene may contain overlapping common genetic risk factors for both major depressive disorder and schizophrenia in the Han Chinese population. The study on variants conferring overlapping risk for multiple psychiatric disorders could be tangible pathogenesis support in clinical or diagnostic references.
三磷酸腺苷结合盒转运超家族是最大的膜蛋白家族之一，负责利用能量将物质跨膜运输。一些研究已经将 ABCA13 的变异与精神疾病的发生联系起来。为了研究 ABCA13 对重度抑郁症和精神分裂症的重叠风险，我们分析了标签单核苷酸多态性（tag SNPs）。
我们使用 TaqMan 技术对 1045 名汉族重度抑郁症患者、1235 名精神分裂症患者和 1235 名健康对照者进行基因分型。
我们发现 rs7789493（P=7.23E-04，P=.001）与重度抑郁症相关，而 rs17132388（P=1.63E-04，P=7.50E-04）和 rs6583476（P=5.50E-04，P=.002）与精神分裂症有统计学显著关联。
我们的结果表明，ABCA13 基因可能在汉族人群中同时包含重度抑郁症和精神分裂症的重叠共同遗传风险因素。对多种精神疾病的重叠风险变异的研究可以为临床或诊断参考提供切实的发病机制支持。
