Wiethan Carson, Franceschini Steffany Z, Bonacorso Helio G, Stradiotto Mark
Departamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, Brazil.
Department of Chemistry, Dalhousie University, Halifax, NS, B3H 4R2 Canada.
Org Biomol Chem. 2016 Sep 21;14(37):8721-8727. doi: 10.1039/c6ob01407k.
An efficient one-pot transition metal-free procedure for the synthesis of new pyrazolo[1,5-a]quinoxalin-4(5H)-ones from easily prepared 1-(2-chlorophenyl-5-ethylcarboxylate)pyrazoles and various primary alkylamines is described. The key steps involved in the synthesis of the new 5,6-fused ring system are the formation of an amide intermediate followed by an intramolecular N-arylation reaction via nucleophilic aromatic substitution.
