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替米沙坦与氨氯地平固定复方制剂在原发性高血压治疗中的现状

[Current position of a fixed combination telmisartan with amlodipine in treatment of essential arterial hypertension].

作者信息

Slíva Jiří

出版信息

Vnitr Lek. 2016 Fall;62(9):699-702.

Abstract

Nowadays, fixed drug combinations are very important part of pharmacotherapy in essential arterial hypertension. The ameliorated activity of RAAS system (ACE inhibitors or sartans) along with calcium-ion channel inhibitor results in additive decrease of blood pressure with concomitant beneficial safety profile. Both telmisartan and amlodipine possess very favorable pharmacological properties, what is reflected in results of performed clinical trials, in which they were used as combinations.Key words: amlodipine - calcium channel blockers - fixed combination - hypertension - sartans - telmisartan.

摘要

如今,固定剂量复方制剂是原发性高血压药物治疗的重要组成部分。肾素-血管紧张素-醛固酮系统(RAAS)抑制剂(血管紧张素转换酶抑制剂或沙坦类药物)与钙离子通道抑制剂联合使用,可使血压进一步降低,同时具有良好的安全性。替米沙坦和氨氯地平都具有非常良好的药理学特性,这在已开展的将它们作为复方制剂使用的临床试验结果中得到了体现。关键词:氨氯地平;钙通道阻滞剂;固定剂量复方制剂;高血压;沙坦类药物;替米沙坦

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